ArticleImmunity2026
Macrophage metabolic exhaustion and PANoptotic cell death drive chronic tissue inflammation in rheumatoid arthritis.
Abstract read
In one paragraph
Article in Immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Tissue-Resident Macrophage in Inflammation and Cancer.MedComm · 2026Review
- Metabolic exhaustion and immune ageing in rheumatoid arthritis.Nature reviews. Rheumatology · 2026Review
- Review
- PANoptosis in the pathogenesis of myelodysplastic syndromes.Molecular oncology · 2026Review
- PANoptosis in life and death across cell types: From innate immunity to therapeutic implications.Cell chemical biology · 2026Review
- NAD+ depletion links metabolic stress to drive innate immune priming and selectively control PANoptosis.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Immune responses in aging adults.The Journal of clinical investigation · 2026Review
- Quantification of SARM1 NADase Activity in Human Peripheral Blood Mononuclear Cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Immunoengineering in the field of tendon and bone regeneration: immunomodulatory biomaterials, delivery platforms, and preclinical models for chronic diseases.Frontiers in bioengineering and biotechnology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Tao HuangDepartment of Medicine, Mayo Clinic Alix School of Medicine, Rochester, MN 55905, USA; Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA; Department of Cardiology, Mayo Clinic Alix School of Medicine, Rochester, MN 55905, USA.
Yoshinori TakashimaDepartment of Medicine, Mayo Clinic Alix School of Medicine, Rochester, MN 55905, USA; Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA; Department of Cardiology, Mayo Clinic Alix School of Medicine, Rochester, MN 55905, USA.
Jitendra KumarDepartment of Medicine, Mayo Clinic Alix School of Medicine, Rochester, MN 55905, USA; Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA; Department of Cardiology, Mayo Clinic Alix School of Medicine, Rochester, MN 55905, USA.
Jose MoralesDepartment of Medicine, Mayo Clinic Alix School of Medicine, Rochester, MN 55905, USA; Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA; Department of Cardiology, Mayo Clinic Alix School of Medicine, Rochester, MN 55905, USA.
Kevin LeDepartment of Medicine, Mayo Clinic Alix School of Medicine, Rochester, MN 55905, USA; Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA; Department of Cardiology, Mayo Clinic Alix School of Medicine, Rochester, MN 55905, USA.
Zhensheng HuDepartment of Medicine, Mayo Clinic Alix School of Medicine, Rochester, MN 55905, USA; Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA; Department of Cardiology, Mayo Clinic Alix School of Medicine, Rochester, MN 55905, USA.
Selene RubinoDepartment of Medicine, Mayo Clinic Alix School of Medicine, Rochester, MN 55905, USA; Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA; Department of Cardiology, Mayo Clinic Alix School of Medicine, Rochester, MN 55905, USA.
Robert T TrousdaleDepartment of Orthopedic Surgery, Mayo Clinic Alix School of Medicine, Rochester, MN 55905, USA.
Gerald J BerryDepartment of Pathology, School of Medicine, Stanford University, Stanford, CA 94305, USA.
Jorg J GoronzyDepartment of Medicine, Mayo Clinic Alix School of Medicine, Rochester, MN 55905, USA; Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA; Department of Medicine, School of Medicine, Stanford University, Stanford, CA 94305, USA.
Cornelia M WeyandDepartment of Medicine, Mayo Clinic Alix School of Medicine, Rochester, MN 55905, USA; Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA; Department of Cardiology, Mayo Clinic Alix School of Medicine, Rochester, MN 55905, USA; Department of Medicine, School of Medicine, Stanford University, Stanford, CA 94305, USA. Electronic address: cweyand@stanford.edu.
Funding
The NOTCH Signaling Pathway in Large Vessel VasculitisR01HL117913 · NHLBI · STANFORD UNIVERSITY · PI WEYAND, CORNELIA M. · 2014 to 2025
$5.0MOligoclonal T Cell Expansion &Rheumatoid ArthritisR01AR042527 · NIAMS · STANFORD UNIVERSITY · PI WEYAND, CORNELIA M. · 1993 to 2022
$4.8MmicroRNA Regulation of T Cell SenescenceR01AI108891 · NIAID · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI GORONZY, JORG J · 2014 to 2023
$4.6MTelomere Damage Responses and Immune AgingR01AI108906 · NIAID · STANFORD UNIVERSITY · PI WEYAND, CORNELIA M. · 2014 to 2024
$4.0MInfluence of Age on CD4 T Memory CellsR01AG045779 · NIA · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI GORONZY, JORG J · 2013 to 2023
$4.0MT Cell Immunity in Giant Cell ArteritisR01HL142068 · NHLBI · STANFORD UNIVERSITY · PI Cornelia M. Weyand · 2018 to 2026
$3.3MMemory T Cell Development and Survival in T Cell Responses of Older IndividualsR01AI129191 · NIAID · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI GORONZY, JORG J · 2017 to 2021
$1.9MMechanisms of genetic variants in TH2 autoimmunityR01AI184360 · NIAID · MAYO CLINIC ROCHESTER · PI JORG J GORONZY · 2024 to 2026
$1.8MMitochondrial Malfunction in T Cell Aging and Tissue InflammationU01AI179609 · NIAID · MAYO CLINIC ROCHESTER · PI Cornelia M. Weyand · 2024 to 2026
$1.7MLipid-Loaded Macrophages in Atherosclerotic Plaque InflammationF30HL177853 · NHLBI · MAYO CLINIC ROCHESTER · PI Kevin-Phu C Le · 2025 to 2026
$100kNHLBI NIH HHS F30 HL177853NHLBI NIH HHS R01 HL117913NHLBI NIH HHS R01 HL142068NIAID NIH HHS R01 AI108891NIAID NIH HHS R01 AI108906NIAID NIH HHS R01 AI129191NIAID NIH HHS R01 AI184360NIAID NIH HHS U01 AI179609NIAMS NIH HHS R01 AR042527NIA NIH HHS R01 AG045779
Abstract
In the autoimmune disease rheumatoid arthritis, the inflammatory response evolves from protective to pathogenic, causing tissue destruction. Rheumatoid synovitis persists despite the presence of pro-repair SELENOP
Indexed as
Arthritis, RheumatoidInflammationMacrophagesAnimalsArmadillo Domain ProteinsCell DeathComplement C1qCyclic ADP-RiboseCytoskeletal ProteinsHumansMiceNADReceptors, ComplementArmadillo Domain ProteinsComplement C1qCyclic ADP-RiboseCytoskeletal ProteinsNADReceptors, ComplementSARM1 protein, humanC1qC1Q-binding proteincADPRmetabolic exhaustionNADNAD(+) hydrolasePANoptosisrheumatoid arthritisSARM1tissue macrophage
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.