Evidence map›Paper›PMID 41794032›Full record

ArticleImmunity2026

HIF-1α

Jean de Lima, Nivedya Swarnalekha, Claire E Depew, Ewelina Bartoszek, Ludivine C Litzler, Mara Esposito, Maike Erber, Tiphaine M N Camarasa, Lorenzo Iseppi, Marco Künzli and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Jean de LimaInfection Immunology Laboratory, Department of Biomedicine, University of Basel, Basel-Stadt 4058, Switzerland.
Nivedya SwarnalekhaInfection Immunology Laboratory, Department of Biomedicine, University of Basel, Basel-Stadt 4058, Switzerland.
Claire E DepewInfection Immunology Laboratory, Department of Biomedicine, University of Basel, Basel-Stadt 4058, Switzerland.
Ewelina BartoszekMicroscopy Core Facility, Department of Biomedicine, University of Basel, Basel-Stadt 4031, Switzerland.
Ludivine C LitzlerInfection Immunology Laboratory, Department of Biomedicine, University of Basel, Basel-Stadt 4058, Switzerland.
Mara EspositoInfection Immunology Laboratory, Department of Biomedicine, University of Basel, Basel-Stadt 4058, Switzerland.
Maike ErberInfection Immunology Laboratory, Department of Biomedicine, University of Basel, Basel-Stadt 4058, Switzerland.
Tiphaine M N CamarasaInfection Immunology Laboratory, Department of Biomedicine, University of Basel, Basel-Stadt 4058, Switzerland.
Lorenzo IseppiInfection Immunology Laboratory, Department of Biomedicine, University of Basel, Basel-Stadt 4058, Switzerland.
Marco KünzliInfection Immunology Laboratory, Department of Biomedicine, University of Basel, Basel-Stadt 4058, Switzerland.
Anukul T ShenoyDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Ines LammensLaboratory of Immunoregulation and Mucosal Immunology, VIB, Ghent 9052, Belgium; Department of Internal Medicine and Pediatrics, Ghent University, Ghent 9000, Belgium.
Stijn VanheeLaboratory of Immunoregulation and Mucosal Immunology, VIB, Ghent 9052, Belgium; Department of Internal Medicine and Pediatrics, Ghent University, Ghent 9000, Belgium; Department of Head and Skin, Ghent University, Ghent 9000, Belgium.
Bart N LambrechtLaboratory of Immunoregulation and Mucosal Immunology, VIB, Ghent 9052, Belgium; Department of Internal Medicine and Pediatrics, Ghent University, Ghent 9000, Belgium; Department of Pulmonary Medicine, Erasmus MC, Rotterdam 3000, the Netherlands.
Ananda W GoldrathAllen Institute for Immunology, Washington, Seattle, WA 98109, USA; Division of Biological Sciences, Section of Molecular Biology, University of California, San Diego, La Jolla, CA 92093, USA.
Jie SunBeirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22908, USA; Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
David SchreinerInfection Immunology Laboratory, Department of Biomedicine, University of Basel, Basel-Stadt 4058, Switzerland.
Carolyn G KingInfection Immunology Laboratory, Department of Biomedicine, University of Basel, Basel-Stadt 4058, Switzerland. Electronic address: carolyn.king@unibas.ch.

Funding

Host cellular network governing the development of post SARS-CoV-2 tissue sequelaeR01AI147394 · NIAID · UNIVERSITY OF VIRGINIA · PI Jie Sun · 2020 to 2026
$4.7M
Roles of tissue-resident helper T cells in mucosal immunity against influenzainfectionR01AI154598 · NIAID · UNIVERSITY OF VIRGINIA · PI SUN, JIE · 2020 to 2024
$2.9M
Determinants of Convalescent and Vaccine-induced Mucosal Specific Immunity to SARS-CoV-2 and Variants of Concern in Children with AsthmaR01AI176171 · NIAID · UNIVERSITY OF VIRGINIA · PI Jie Sun, WILLIAM GERALD TEAGUE · 2023 to 2026
$2.7M
Uncover mechanisms underlying the development of chronic lung sequelae post COVID-19R01HL170961 · NHLBI · UNIVERSITY OF VIRGINIA · PI Jie Sun, ROBERT VASSALLO · 2023 to 2026
$2.7M
Tissue-specific adaptions to promote localized T cell memoryR01AI179952 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ananda W Goldrath · 2024 to 2026
$1.8M
Lung epithelial cell reprogramming by CD4 T cellsR00HL157555 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHENOY, ANUKUL T · 2023 to 2025
$747k
NHLBI NIH HHS R00 HL157555NHLBI NIH HHS R01 HL170961NIAID NIH HHS R01 AI147394NIAID NIH HHS R01 AI154598NIAID NIH HHS R01 AI176171NIAID NIH HHS R01 AI179952
6 · The paper itself

Abstract

A deeper understanding of how tissue-localized immune cells arise and function is critical for developing mucosal vaccines. Currently, there are no murine models that specifically target tissue T cells while leaving their lymphoid counterparts untouched. Here, we leverage the observation that during influenza infection, HIF-1α regulatory activity is higher in the lung compared with lymph node CD4

Indexed as

CD4-Positive T-LymphocytesHypoxia-Inducible Factor 1, alpha SubunitLungAnimalsB-LymphocytesKiller Cells, NaturalLung NeoplasmsLymph NodesMacrophagesMiceMice, Inbred C57BLMice, KnockoutOrthomyxoviridae InfectionsHif1a protein, mouseHypoxia-Inducible Factor 1, alpha SubunitCD4Hif1-alphainfluenzalungtertiary lymphoid structureT follicular helpertissue

Identifiers

PMID41794032
PMCPMC13401729

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.