ArticleAsian Pacific journal of cancer prevention : APJCP2026
Impact of Optimization Resolution and Dose Calculation Grid Size in Small-Field Stereotactic Body Radiotherapy Using Flattening-Filter-Free Beams for Hepatocellular Carcinoma.
Article in Asian Pacific journal of cancer prevention : APJCP, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Abstract
objectiveThis study aims to evaluate the impact of optimization and calculation resolutions in SBRT for hepatocellular carcinoma (HCC) using flattening-filter-free photon beams.
methodsThe SBRT plans were created in the Eclipse TPS using 6X-FFF and 10X-FFF MV photon beams, prescribed with a hypofractionated dose of 50 Gy in 5 fractions. A total of 4 plans were created for each energy with different combinations of optimization (O) and calculation (C) resolutions, viz. O1.25-C1.25, O1.25-C2.5, O2.5-C1.25, and O2.5-C2.5, using computed tomography (CT) images of fifteen HCC patients. The optimization and calculation times were noted for comparison among all plans. The plans were evaluated based on the PTV, organs at risk, and delivery efficiency dosimetric parameters, and a plan quality score was computed for each plan.
resultsThis study revealed that the 10X-FFF beams provided better results compared to 6X-FFF. The integrated scoring method revealed that the O1.25-C1.25 plan achieved better results for OARs, while O1.25-C2.5 plan achieved better results for PTV. Further, the optimization and calculation times, and phantom study results were better with 2.5 mm resolution plans.
conclusionThe 1.25 mm resolution for both optimization and calculation was found to be better if the critical organs are in prioritized; otherwise, the 2.5 mm resolution setting is the optimal choice for liver SBRT using the 10X-FFF beam.
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