Evidence map›Paper›PMID 41793657›Full record

ReviewAsian Pacific journal of cancer prevention : APJCP2026

Molecular Mechanisms of FAT Atypical Cadherin 1 (FAT1), the Hippo Pathway, and the Yes-Associated Protein (YAP) Signaling Pathways in Some Cancers.

Roland Osei Saahene, Precious Barnes, Du-Bois Asante, Sylvester Ackah Famieh, Elvis Agbo

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Asian Pacific journal of cancer prevention : APJCP, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Roland Osei SaaheneDepartment of Microbiology and Immunology, School of Medical Sciences, College of Health and Allied Sciences, University of Cape Coast, Ghana.
Precious BarnesDepartment of Chemical Pathology, School of Medical Sciences, College of Health and Allied Sciences, University of Cape Coast, Ghana.ORCID 0000-0002-9229-5605
Du-Bois AsanteDepartment of Forensic Sciences, School of Biological Sciences, College of Agricultural and Natural Sciences, University of Cape Coast, Ghana.
Sylvester Ackah FamiehDepartment of Physician Assistant Studies, School of Medical Sciences, College of Health and Allied Sciences University of Cape Coast, Ghana.
Elvis AgboDepartment of Human Anatomy, Histology and Embryology, College of Medicine, Jinggangshan University, Ji'an City, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introuduction: FAT atypical cadherin 1 (FAT1), the Hippo pathway and Yes-associated protein (YAP) signaling play significant roles in cell proliferation, differentiation, and apoptosis. Dysregulation of these pathways contributes to tumorigenesis in multiple cancers, including head and neck squamous cell carcinoma (HNSCC), hepatocellular carcinoma (HCC), and breast cancer.

methodsThe FAT atypical cadherin 1 (FAT1) gene is an ortholog of the Drosophila fat gene, which encodes the protocadherin FAT1. FAT1 is one of the most mutated genes and is therefore considered to be an emerging cancer biomarker and a potential therapeutic target for novel therapies. However, the molecular mechanisms of the FAT1 signaling pathways it mediates has not been fully elucidated.

resultsThe Hippo-YAP pathway is considered a crucial oncogenic pathway in multiple tumors. The expression of genes controlled by the Hippo downstream transcriptional coactivators Yes-associated protein 1 (YAP) is widely deregulated in different human cancers, including head and neck squamous cell carcinoma (HNSCC).

conclusionThis review discusses the FAT1, Hippo and Yap genes, with a focus on their mutations and expression levels, and their impact on signaling pathways and mechanisms in various types of cancer.

Indexed as

Adaptor Proteins, Signal TransducingCadherinsNeoplasmsProtein Serine-Threonine KinasesSignal TransductionTranscription FactorsAnimalsCell Cycle ProteinsGene Expression Regulation, NeoplasticHippo Signaling PathwayHumansYAP-Signaling ProteinsAdaptor Proteins, Signal TransducingCadherinsCell Cycle ProteinsFAT1 protein, humanProtein Serine-Threonine KinasesTranscription FactorsYAP1 protein, humanYAP-Signaling ProteinsEGFR familyHERSTAT3Wnt/β-catenin

Identifiers

PMID41793657
PMCPMC13552981

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.