ArticleAsian Pacific journal of cancer prevention : APJCP2026
Salivary Malondialdehyde as a Marker of Oxidative Stress in Tobacco Chewers, with and without Oral Submucous Fibrosis: A Comparative, Cross-Sectional Biochemical Study.
Article in Asian Pacific journal of cancer prevention : APJCP, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to evaluate and compare salivary Malondialdehyde (MDA) levels in tobacco chewers with and without oral submucous fibrosis, and healthy individuals, and correlate the levels with stages of oral submucous fibrosis.
methodsThis cross-sectional study was conducted in ITS-Centre for Dental Studies and Research, Ghaziabad, India which included 60 subjects divided into three groups: Group A: Healthy controls (n=20) Group B: Tobacco chewers with clinically and histopathologically confirmed Oral Submucous Fibrosis (OSMF) (n=20) Group C: Tobacco chewers without OSMF (n=20). Unstimulated whole saliva was collected, centrifuged, and stored at -20°C. Salivary MDA levels were estimated by enzyme-linked immunosorbent assay (ELISA) using thiobarbituric acid reactive substances (TBARS).
resultsSalivary MDA levels were significantly higher in oral submucous fibrosis patients (mean ± SD: 49.57 ± 25.91 mmol/L) compared to tobacco chewers without oral submucous fibrosis (21.21 ± 7.76 mmol/L) and healthy individuals (10.96 ± 2.90 mmol/L),with p < 0.001. A statistically significant positive correlation was found between MDA levels and stages of oral submucous fibrosis, indicating increased oxidative stress with disease progression.
conclusionElevated salivary MDA levels in oral submucous fibrosis patients reflect increased oxidative stress and its correlation with disease severity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.