ArticleJournal of autism and developmental disorders2026
Identifying Neurodevelopmental Domain Subgroups in Autism and ADHD.
Article in Journal of autism and developmental disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
purposeAutism Spectrum Disorder (ASD) and Attention Deficit Hyperactivity Disorder (ADHD) have considerable overlap in clinical presentation, supporting the need for a framework of symptom domains which crosses traditional diagnostic boundaries. We aimed to identify latent groups based on similarities in factor scores across ASD and ADHD neurodevelopmental domains and to compare these groups on adaptive functioning and neuroimaging measures.
methodsParticipants included children and youth with a clinical diagnosis of ASD (n = 727) or ADHD (n = 770). Parents completed measures of autism and ADHD symptoms. We identified latent profiles of four symptom factors (inattention, hyperactivity/impulsivity, social communication, and restricted, repetitive behaviours and interests). The profiles were then compared on adaptive functioning and global structural and functional neuroimaging measures.
resultsA four-profile model was the best fitting model. All four profiles had varying levels of co-occurring ASD and ADHD symptoms, regardless of whether the class consisted of predominately ASD or ADHD participants. There was no profile with all ASD or ADHD participants. Adaptive Behavior Assessment System scores were significantly different among latent profiles after adjusting for age, sex and diagnosis (Χ2(3) = 360.747, p < 0.001). Total subcortical volume was significantly different among latent profiles after adjusting for age, sex, and brain volume (Χ2(4) = 10.868, p = 0.028).
conclusionsWe identified four latent profiles with varying levels of co-occurring ASD and ADHD symptoms, spanning diagnostic labels, and between-profile variation on adaptive functioning and subcortical volume. These results provide support for phenotypic overlap between ASD and ADHD and reinforce the need to focus on dimensionality in ASD and ADHD.
Indexed as
Identifiers
41793610What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.