ArticleApoptosis : an international journal on programmed cell death2026
Traffic and functional polarization of macrophages in the areas of programmed interdigital cell death in the embryonic chick.
Article in Apoptosis : an international journal on programmed cell death, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we show that during digit development, the embryonic limb contains an abundant and widespread population of "resident macrophages" that precede the onset of interdigital cell death responsible for the separation of digit primordia. The use of cultures of interdigital mesoderm at different remodeling stages, and GFP+ transgenic embryos in which the distal part of the autopodium has been surgically replaced by a fragment with identical characteristics from wild-type embryos, indicate that "transient macrophages" are also recruited at the beginning of interdigital death. The expression of the Pu.1 gene in coincidence with the onset of interdigital death suggests that primary yolk-sac macrophages are later complemented by macrophages of hematopoietic origin. Q-PCR analysis revealed a predominant M2/anti-inflammatory gene signature in the interdigits during the whole remodeling process that correlated with an interdigital transcriptome including Csf1, Il-34, Igf1, Igfbp5, Tgfβ4 (Tgfβ1 in mammals), P75
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.