Evidence map›Paper›PMID 41793512›Full record

ArticleApoptosis : an international journal on programmed cell death2026

Spatially defined danger zone shapes gastric cancer progression through CCDC80

Shaocong Mo, Yulin Wang, Rong Xiong, Liqiu Ma, Midie Xu, Lei Wang, Wenchao Gu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Apoptosis : an international journal on programmed cell death, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shaocong Mo *Department of Digestive Diseases, Huashan Hospital, Fudan University, Shanghai, China.
Yulin Wang *Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.
Rong Xiong *Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Liqiu MaDepartment of Molecular Imaging and Theranostics, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba, Japan.
Midie XuDepartment of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China. midiexu12@fudan.edu.cn.
Lei WangDepartment of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China. wanglei056713@163.com.
Wenchao GuDepartment of Artificial Intelligence Medicine, Graduate School of Medicine, Chiba University, Chiba, 263-8522, Japan. sunferrero@gmail.com.

Funding

National Natural Science Foundation of China 823B2082
6 · The paper itself

Abstract

Gastric cancer (GC) shows marked heterogeneity driven by the tumor microenvironment, leading to therapeutic resistance and poor prognosis. Using spatial transcriptomics of invasive murine tumors and human GC samples, we identified a distinct stromal-immune-vascular core region, termed the 'danger zone', which is enriched in diffuse-type GC and strongly linked to advanced stage and an immunosuppressive tumor microenvironment. Non-negative matrix factorization using danger zone signature genes stratified GC patients into two subtypes, with Subtype 2 exhibiting worse survival and impaired immunotherapy response. An XGBoost classifier based on 13 key genes-including CCDC80, MSRB3, FBLN1, and SPARCL1-accurately predicted subtypes and prognosis across cohorts. Single-cell and spatial analyses identified CCDC80

Indexed as

CD8-Positive T-LymphocytesFibroblastsStomach NeoplasmsAnimalsApoptosisCell Line, TumorChemokine CXCL12Disease ProgressionGene Expression Regulation, NeoplasticHumansMicePrognosisReceptors, CXCR4Signal TransductionTumor MicroenvironmentChemokine CXCL12CXCL12 protein, humanCxcl12 protein, mouseReceptors, CXCR4CCDC80CXCL12Danger zoneFibroblastsGastric cancerSpatial

Identifiers

PMID41793512
PMCPMC12967633

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.