Evidence map›Paper›PMID 41793481›Full record

ArticleEuropean journal of nutrition2026

Relationship between habitual glucosamine use and risk of incident idiopathic pulmonary fibrosis with the modification effect of genetic susceptibility: a prospective cohort study.

Liangle Yang, Yujia Xie, Yuxin Yao, Haoyu Yin, Bingxin Shang, Shiyu Yang, Xiaojie You, Jixuan Ma

Abstract read
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Article in European journal of nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Liangle Yang *Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Yujia Xie *Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Yuxin YaoKey Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Haoyu YinKey Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Bingxin ShangKey Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Shiyu YangKey Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Xiaojie YouKey Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Jixuan MaKey Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China. maj@hust.edu.cn.ORCID http://orcid.org/0000-0003-0644-0157

Funding

National Natural Science Foundation of China 82273605Natural Science Foundation of Hubei Province 2024AFB548
6 · The paper itself

Abstract

purposeWe aimed to investigate the relationship between habitual glucosamine use and the risk of incident idiopathic pulmonary fibrosis (IPF). Moreover, we assessed the modification effect of genetic predisposition on such association.

methodsWe analyzed 472,615 individuals from the UK Biobank. The genetic risk score (GRS) for IPF was constructed. The Cox proportional hazard models were fitted to estimate the association.

resultsDuring a median of 12.5 years of follow-up, 1870 incident cases of IPF were identified. After adjusting for potential covariates, we observed that glucosamine intake was related to a reduced risk of IPF. Moreover, an additive interaction and joint effect were observed between non-users of glucosamine and genetic susceptibility on the development of IPF.

conclusionThese findings suggested that habitual glucosamine consumption was related to a lower incidence of IPF, and this relationship could be influenced by genetic susceptibility.

Indexed as

Genetic Predisposition to DiseaseGlucosamineIdiopathic Pulmonary FibrosisAgedFemaleGenetic Risk ScoreHumansIncidenceMaleMiddle AgedPolymorphism, Single NucleotideProportional Hazards ModelsProspective StudiesRisk FactorsUnited KingdomGlucosamineAdditive interactionChronic respiratory diseaseDietary supplementSingle nucleotide polymorphism

Identifiers

PMID41793481

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.