Evidence map›Paper›PMID 41793474›Full record

ArticleCancer immunology, immunotherapy : CII2026

A STING-activating biomimetic mineralized nanovaccine triggers robust anti-tumor immunity.

Suxing Tuo, Yihan Wang, Meng Tian, Lixia Su, Jing Dong, Kefeng Lv, Wencan He, Qing Feng, Shan Chen, Daozhu Dong and 5 more

Abstract read
In one paragraph

Article in Cancer immunology, immunotherapy : CII, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Suxing Tuo *China Tobacco Hunan Industrial Co., Ltd., Changsha, 410019, Hunan, People's Republic of China.
Yihan Wang *The Third Hospital of Changsha (Changsha Hospital affiliated to Hunan University), Changsha, 410015, Hunan, People's Republic of China.
Meng Tian *College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, Hunan, People's Republic of China.
Lixia Su *China Tobacco Hunan Industrial Co., Ltd., Changsha, 410019, Hunan, People's Republic of China.
Jing DongThe Third Hospital of Changsha (Changsha Hospital affiliated to Hunan University), Changsha, 410015, Hunan, People's Republic of China.
Kefeng LvThe Third Hospital of Changsha (Changsha Hospital affiliated to Hunan University), Changsha, 410015, Hunan, People's Republic of China.
Wencan HeChina Tobacco Hunan Industrial Co., Ltd., Changsha, 410019, Hunan, People's Republic of China.
Qing FengThe Third Hospital of Changsha (Changsha Hospital affiliated to Hunan University), Changsha, 410015, Hunan, People's Republic of China.
Shan ChenThe Third Hospital of Changsha (Changsha Hospital affiliated to Hunan University), Changsha, 410015, Hunan, People's Republic of China.
Daozhu DongChina Tobacco Hunan Industrial Co., Ltd., Changsha, 410019, Hunan, People's Republic of China.
Xiaoxu LiChina Tobacco Hunan Industrial Co., Ltd., Changsha, 410019, Hunan, People's Republic of China.
Kejun ZhongChina Tobacco Hunan Industrial Co., Ltd., Changsha, 410019, Hunan, People's Republic of China.
Yueming ZhangThe Third Hospital of Changsha (Changsha Hospital affiliated to Hunan University), Changsha, 410015, Hunan, People's Republic of China. zhangyueming00@hotmail.com.
Bo KongChina Tobacco Hunan Industrial Co., Ltd., Changsha, 410019, Hunan, People's Republic of China. kongb0706@hngytobacco.com.
Lan HeThe Third Hospital of Changsha (Changsha Hospital affiliated to Hunan University), Changsha, 410015, Hunan, People's Republic of China. helan2019@hnu.edu.cn.

Funding

Natural Science Foundation of Hunan Province of China 2023JJ60063
6 · The paper itself

Abstract

Tumor nanovaccines have attracted great interest recently, due to a variety of advantages including high stability, efficient antigen packing and delivery, and the capacity to elicit sustained anti-tumor immune responses. Despite these advantages, existing nanovaccines are constrained by intricate manufacturing procedures and high production costs, prompting a need to develop simpler and more cost-effective solutions. In this study, we introduce a novel STING-activating tumor nanovaccine, designated OVA/Tp@Mn-DNA. The preparation of OVA/Tp@Mn-DNA nanovaccine is a straightforward process involving the self-assembly of Mn

Indexed as

Biomimetic MaterialsCancer VaccinesMembrane ProteinsNeoplasmsAnimalsAntigen-Presenting CellsCell Line, TumorcGAS-STING Signaling PathwayFemaleHumansImmunotherapyMiceNanovaccinesOvalbuminSTING ProteinCancer VaccinesMembrane ProteinsNanovaccinesOvalbuminSting1 protein, mouseSTING ProteinMn-DNA nanospheresNanovaccineSR-B1STING-activating nanovaccineTumor immunotherapy

Identifiers

PMID41793474
PMCPMC12967781

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.