SynthesisEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2026
Cervical spine fracture patterns associated with blunt cerebrovascular injuries: A literature review and meta-analysis.
Synthesis in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeCervical spine fractures (CSF) have been linked to blunt cerebrovascular injuries (BCVI) due to arterial proximity, but consensus on screening criteria remains elusive. This literature review hypothesises that BCVI rates differ with CSF types and aims to identify predictive CSF patterns for BCVI, enhancing screening accuracy and diagnostics.
methodsAll English literature (2000-2026) was reviewed according to PRISMA guidelines in PubMed and Embase. Inclusion criteria were adults (> 16 years), blunt cervical trauma, and specific CSF patterns associated with BCVI. Exclusion criteria were pediatric patients, penetrating traumas, and no accessible full text. A random-effects meta-analysis was conducted to produce pooled odds ratios with a corresponding 95% confidence interval for each specific fracture pattern. I2-statistics were calculated to assess the proportion of variation attributed to heterogeneity and whether that variation was significant. Leave-one-out analysis was conducted on estimates with significant heterogeneity Calculations were made using Stata18.
resultsAmong 717 eligible articles, 7 studies met the criteria. Specific CSF patterns mentioned were isolated C1 and C2 fractures, any C1-C3 and C4-C7 fractures, two-level fractures, subluxation/dislocations, and transverse foramen (TF) fractures. Pooled odds ratio with 95% confidence interval for BCVI and C1 fractures was: 1.38 (0.97-1.94); C2: 1.18 (0.88-1.58); C1-C3: 1.89 (0.99-3.60); C4-C7: 0.98 (0.61-1.59); TF: 3.42 (1.61-7.26); Subluxation/dislocations: 4.41 (2.88-6.76); Two-level: 1.19 (0.78-1.82).
conclusionThis meta-analysis showed an association between facet dislocations and fractures involving the transverse foramen and increased odds of BCVI. No statistically significant association was identified between BCVI and fractures at specific vertebral levels, although upper cervical fractures were frequently observed among affected patients. Heterogeneity between studies calls for caution when interpreting results.
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