ArticleBulletin of environmental contamination and toxicology2026
The Accumulation and Distribution of Green Synthesized Silver Nanoparticles with Açaí in C. elegans Do Not Cause Redox Toxicity.
Article in Bulletin of environmental contamination and toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
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12 authors.
Funding
Abstract
Green synthesis of silver nanoparticles (AgNP) has been proposed as a safer and more sustainable alternative for AgNP production. However, limited information exists on the toxicity mechanisms and accumulation of green-synthesized AgNP. In this study, we used AgNP synthesized with Amazonian açaí (Bio-AgNP) to evaluate their accumulation and biochemical effects in Caenorhabditis elegans. Bio-AgNP were synthesized using aqueous extract of lyophilized açaí pulp as reducing and stabilizing agent. Caenorhabditis elegans N2 wild-type (L1 larvae) were exposed to 5 and 10 mg/L Bio-AgNP for 52 h. Silver accumulation and distribution were assessed, and GSH and GSSG levels quantified. Our results showed that Bio-AgNP accumulated in C. elegans (3.6 ± 0.5 and 17.9 ± 1.8 pg Ag/µg protein, respectively), distributed throughout the body, particularly in the midgut. However, no statistical significant changes in GSH or GSSG were detected. Overall, Bio-AgNP accumulate in C. elegans without affecting the GSH/GSSG redox balance, These findings support the potential of green chemistry as a sustainable pathway for nanoparticle production with reduced toxicological impact compared with AgNP produced by chemical synthesis.
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