ArticleThe clinical respiratory journal2026
Association Between Unsaturated Fatty Acid Levels and Chronic Obstructive Pulmonary Disease: A Bidirectional Mendelian Randomization Study.
Article in The clinical respiratory journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
backgroundObservational studies have revealed that the levels of unsaturated fatty acids (UFAs) may influence the development, progression, and management of chronic obstructive pulmonary disease (COPD). To investigate the association between UFAs and COPD, we performed a bidirectional Mendelian randomization (MR) study.
methodsWe extracted summary genome-wide association statistics (GWAS) for UFAs (N = 115 082) among population from UK Biobank study by measuring circulating lipoprotein lipid concentrations. The genetic instrument for COPD was derived from the FinnGen, which included 338 303 COPD controls and 20 066 cases of the disease. Measured at the genome-wide significance level, independent genetic variations associated with each characteristic were considered instrumental factors. Two-sample MR analysis was mainly conducted utilizing the inverse-variance-weighted (IVW) approach, complemented by the weighted median method and the MR-Egger regression.
resultsIVW MR analysis significantly demonstrated that the level of docosahexaenoic acid (DHA) (OR 0.812, 95% CI 0.719-0.918, p < 0.001), linoleic acid (LA) (OR 0.850, 95% CI 0.781-0.926, p < 0.001), the levels of omega-3 fatty acids (OR 0.884, 95% CI 0.781-0.99, p = 0.049), omega-6 fatty acids (OR 0.878, 95% CI 0.812-0.950, p = 0.001), and polyunsaturated fatty acids (PUFAs) (OR 0.901, 95% CI 0.827-0.982, p = 0.018) all linked to a higher risk of COPD. Moreover, in reverse direction MR analysis, genetic liability to COPD showed associations with higher levels of monounsaturated fatty acids (MUFAs) (OR 1.040, 95% CI 1.010-1.071, p = 0.008). Horizontal pleiotropy is not likely to materially skew the causative estimates from sensitivity analysis.
conclusionOur research added credence to the current evidence that suggests a bidirectional causal link between UFAs and COPD. It is imperative to comprehend this connection in order to effectively prevent and manage COPD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.