Evidence map›Paper›PMID 41793320›Full record

Observational studyActa ophthalmologica2026

Ultrasound, PET/CT or temporal artery biopsy for giant cell arteritis? A prospective diagnostic accuracy study (the GAME-study).

Michael S Hansen, Lene Terslev, Uffe M Døhn, Viktoria Fana, Jane M Brittain, Anne K Wiencke, Steffen Heegaard, Mads R Jensen, Oliver N Klefter, Yousif Subhi and 1 more

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Acta ophthalmologica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05248906 (Giant Cell Arteritis - Examination of the Optimal Diagnostic Pathway), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05248906 completednot on this map

Giant Cell Arteritis - Examination of the Optimal Diagnostic Pathway

TypeobservationalSponsorRigshospitalet, DenmarkRan2021 to 2024Enrolled110ConditionsGiant Cell ArteritisArmsGiant cell arteritis
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Michael S HansenDepartment of Ophthalmology, Rigshospitalet, Copenhagen, Denmark.ORCID https://orcid.org/0000-0001-8610-7455
Lene TerslevDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.ORCID https://orcid.org/0000-0001-8193-9471
Uffe M DøhnDepartment of Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark.ORCID https://orcid.org/0009-0006-5493-7319
Viktoria FanaDepartment of Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark.ORCID https://orcid.org/0009-0005-4526-8064
Jane M BrittainDepartment of Clinical Physiology and Nuclear Medicine, Rigshospitalet, Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-7456-6213
Anne K WienckeDepartment of Ophthalmology, Rigshospitalet, Copenhagen, Denmark.ORCID https://orcid.org/0009-0002-5996-7841
Steffen HeegaardDepartment of Ophthalmology, Rigshospitalet, Copenhagen, Denmark.ORCID https://orcid.org/0000-0001-5906-7670
Mads R JensenDepartment of Clinical Physiology and Nuclear Medicine, Bispebjerg Hospital, Copenhagen, Denmark.
Oliver N KlefterDepartment of Ophthalmology, Rigshospitalet, Copenhagen, Denmark.ORCID https://orcid.org/0000-0003-2313-5648
Yousif SubhiDepartment of Ophthalmology, Rigshospitalet, Copenhagen, Denmark.ORCID https://orcid.org/0000-0001-6620-5365
Steffen HamannDepartment of Ophthalmology, Rigshospitalet, Copenhagen, Denmark.ORCID https://orcid.org/0000-0003-4318-2716

Funding

Gigtforeningen (The Danish Rheumatism Association) R201-A7279Gigtforeningen (The Danish Rheumatism Association) R218-A7908Synoptik-Fonden
6 · The paper itself

Abstract

purposeTo investigate the diagnostic performance of ultrasound, 2-deoxy-2-[

methodsThis was a prospective single-centre diagnostic accuracy study (ClinicalTrials.gov NCT05248906). One hundred and ten patients suspected of GCA were considered, of which 103 were analysed, 100 had a final diagnosis and 58 had complete data for all modalities. Ultrasound, 2-[

resultsSixty-one patients had GCA, 39 had non-GCA and 3 had inconclusive. The sensitivities were 82% (95% CI: 66%-92%), 74% (95% CI: 57%-87%) and 68% (95% CI: 51%-83%) for ultrasound, 2-[

conclusionUltrasound had high diagnostic accuracy for GCA, supporting this as the first imaging modality in suspected GCA. 2-[

Indexed as

Giant Cell ArteritisPositron Emission Tomography Computed TomographyTemporal ArteriesAgedAged, 80 and overBiopsyFemaleFluorodeoxyglucose F18Follow-Up StudiesHumansMaleMiddle AgedProspective StudiesRadiopharmaceuticalsReproducibility of ResultsSensitivity and SpecificityFluorodeoxyglucose F18Radiopharmaceuticals2‐[18F]FDG PET/CTGiant cell arteritisparacentral acute middle maculopathytemporal artery biopsyultrasound

Identifiers

PMID41793320
PMCPMC13460362

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.