Evidence map›Paper›PMID 41793310›Full record

ArticleInternational journal of cancer2026

Arp2/3 complex and β1 integrin drive an invasive front through extracellular matrix adaptation in pancreatic cancer.

Xiufen Yang, Yina Qiao, Yifeng Sun, Tamer Abdelaal, Kathleen Schuck, Hend Abdelrasoul, Carolina De La Torre, Malte Hermes, Yan Dong, Jingxiong Hu and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Xiufen YangDepartment of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
Yina QiaoDepartment of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
Yifeng SunDepartment of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
Tamer AbdelaalDepartment of General and Visceral Surgery, Ulm University Hospital, Ulm, Germany.
Kathleen SchuckDepartment of General and Visceral Surgery, Ulm University Hospital, Ulm, Germany.
Hend AbdelrasoulDepartment of General and Visceral Surgery, Ulm University Hospital, Ulm, Germany.
Carolina De La TorreCore Facility Platform Mannheim, NGS Core Facility, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Malte HermesDepartment of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
Yan DongDepartment of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
Jingxiong HuDepartment of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
Chao FangDepartment of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
Xiaoyan HuangDepartment of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.ORCID 0000-0001-6306-6080
Christoph KahlertDepartment of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
Ingrid HerrDepartment of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.ORCID 0000-0002-2389-6300
Christoph W MichalskiDepartment of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
Bo KongDepartment of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.

Funding

Hans Beger Stiftung 17-02-2022Wilhelm Sander-Stiftung 2022.135.1
6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest malignancies, due to its aggressive invasiveness and resistance to therapy. The dense, stiff extracellular matrix, composed primarily of collagen I and basement membrane components such as collagen IV and laminin, acts as a mechanical barrier that constrains PDAC invasion. We investigated whether the actin-related protein (Arp) 2/3 complex, a key actin nucleator, is essential for PDAC cells to overcome extracellular matrix stiffness and facilitate migration. CRISPR/Cas9 knockout of the Arpc4 gene in murine PDAC cell lines derived from Kras

Indexed as

Actin-Related Protein 2-3 ComplexCarcinoma, Pancreatic DuctalExtracellular MatrixIntegrin beta1Pancreatic NeoplasmsAnimalsCell Line, TumorCell MovementHumansMiceMice, TransgenicNeoplasm InvasivenessSignal TransductionActin-Related Protein 2-3 ComplexIntegrin beta1Arp2/3extracellular matrixintegrinpancreatic cancertype I collagen

Identifiers

PMID41793310
PMCPMC13047250

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.