ArticleInternational journal of laboratory hematology2026
Efficacy and Safety of Vortexing as a Practical Solution for Resolving Platelet Clumping in hematology laboratories.
Article in International journal of laboratory hematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionPlatelet clumping is a pre-analytical artifact that leads to spurious thrombocytopenia, complicating laboratory interpretation and triggering unnecessary clinical interventions. Vortexing has been proposed as a corrective measure, yet the optimal duration, its applicability to transported samples, and its impact on WBC and RBC parameters remain poorly defined. This study aims to evaluate the efficacy and safety of vortexing across different durations to establish it as a standardized intervention in hematology laboratories.
methodsA total of 730 EDTA-anticoagulated blood samples were analyzed. Samples were vortexed at 3200 rpm for 30 s, 1, or 2 min, using a fixed-speed vortex mixer. Platelet counts and interpretative messages were compared before and after vortexing using the Sysmex XN-10 platform. Stability of WBC and RBC parameters was also assessed.
resultsVortexing significantly reduced platelet clumping flags, with 66% overall resolution and the highest effect in the 101-150 × 10
conclusionVortexing is a reliable, reproducible, and practical method for resolving platelet clumping in EDTA samples without compromising sample integrity. Its implementation can reduce redraws, minimize manual smear reviews, and streamline sample processing in high-volume hematology laboratories.
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