Evidence map›Paper›PMID 41793102›Full record

ArticleArchiv der Pharmazie2026

Synthesis of Some Novel Chalcone and 3,5-Disubstituted Pyrazoline Derivatives: Evaluation of Their α-Amylase and α-Glucosidase Inhibitory Activities In Vitro and In Silico.

Fatma Erbay, Melike Yildirim Akatin, Fatma Demir, Nuran Kahriman, Ahmet Colak, Nagihan Saglam Ertunga, Murat Küçük

Abstract read
In one paragraph

Article in Archiv der Pharmazie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Fatma ErbayGraduate School of Natural and Applied Science, Karadeniz Technical University, Trabzon, Türkiye.
Melike Yildirim AkatinMacka Vocational School, Karadeniz Technical University, Trabzon, Türkiye.ORCID https://orcid.org/0000-0003-4195-4647
Fatma DemirFaculty of Science, Department of Chemistry, Karadeniz Technical University, Trabzon, Türkiye.
Nuran KahrimanFaculty of Science, Department of Chemistry, Karadeniz Technical University, Trabzon, Türkiye.
Ahmet ColakFaculty of Science, Department of Chemistry, Karadeniz Technical University, Trabzon, Türkiye.ORCID https://orcid.org/0000-0003-2291-8800
Nagihan Saglam ErtungaFaculty of Science, Department of Chemistry, Karadeniz Technical University, Trabzon, Türkiye.ORCID https://orcid.org/0000-0002-2104-2192
Murat KüçükFaculty of Science, Department of Chemistry, Karadeniz Technical University, Trabzon, Türkiye.

Funding

Scientific Research Projects Coordination Unit of Karadeniz Technical University FYL-2023-10815
6 · The paper itself

Abstract

This study reports the synthesis of some novel chalcone (C1-C3) and 3,5-disubstituted pyrazoline derivatives (P1-P3), structurally based on aminophenyl and trifluoromethylphenyl groups. Their potential as antidiabetic agents was evaluated through in vitro inhibition of α-amylase and α-glucosidase enzymes and supported by molecular docking studies. Among all the compounds, P2 showed potent dual inhibition, with IC

Indexed as

alpha-Amylasesalpha-GlucosidasesChalconePyrazolesMolecular Docking Simulationalpha-Amylasesalpha-GlucosidasesChalconePyrazoleschalconesmolecular modelingpyrazolinesα‐amylase inhibitionα‐glucosidase inhibition

Identifiers

PMID41793102
PMCPMC12966812

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.