ArticleJournal of cosmetic dermatology2026
Enhancement of the Moisturizing Effect in an Injectable Sodium Hyaluronate Composite Solution by the Addition of Glycine, Alanine, and Proline.
Article in Journal of cosmetic dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
Funding
Abstract
backgroundHyaluronate (HA) is widely utilized in skin rejuvenation treatments, yet mono-component injectable sodium hyaluronate solution (ISHA) is limited by its modest moisturizing performance and frequent dosing requirements. The combination of HA with active ingredients such as amino acids represent a promising strategy to improve hydration efficacy.
aimsThis study aimed to develop a novel injectable sodium hyaluronate composite solution (Co-ISHA) incorporating three amino acids-glycine, alanine, and proline-and to systematically evaluate its moisturizing effects through phenomenological and mechanistic analyses at cellular and tissue levels.
methodsThis study developed a novel Co-ISHA containing glycine, alanine, and proline, and evaluated its moisturizing performance through a comprehensive in vitro assessment system. The reparative and protective effects of Co-HA on cells and tissues under dry conditions were examined, along with the expression of moisturizing-related genes and natural moisturizing factors (NMF). This system integrated both cellular and tissue-level models to elucidate the underlying mechanisms.
resultsThe results indicated that the addition of these three amino acids significantly enhanced the moisturizing efficacy of hyaluronic acid (HA). Both cellular and tissue-level evidence confirmed that, compared to single-component HA, Co-ISHA more effectively protected and repaired cells damaged by dryness and promoted the production of moisturizing-related genes and NMF.
conclusionThis study successfully developed a Co-ISHA formulation with superior moisturizing properties and established a robust in vitro evaluation system for assessing hydration efficacy. The findings provide a strategic framework for advancing the development of "Cruelty-Free" cosmetic products.
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