ArticleMolecular plant pathology2026
ZmWRKY92-Mediated miR169s/NF-YA13 Module Confers Maize Resistance to Bipolaris maydis by Activating Flavonoid Biosynthesis.
Article in Molecular plant pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Temporal Change, Frequency, and Spatial Distribution of Mating Types ofJournal of fungi (Basel, Switzerland) · 2026Article
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8 authors.
Funding
Abstract
MicroRNAs (miRNAs) are pivotal regulators of plant immunity. While our prior work implicated zma-miR169s in maize defence against Bipolaris maydis, its upstream regulation and downstream signalling mechanisms remained elusive. Here, we decipher a complete signalling pathway that confers resistance to B. maydis. We show that the transcription factor ZmWRKY92 directly binds to the promoter of zma-miR169s to suppress its transcription. Consistent with its role as a positive regulator, loss of ZmWRKY92 function increased maize susceptibility to the pathogen. We further delineate downstream of this pathway, demonstrating that ZmNF-YA13, a nuclear-localised target of zma-miR169s induced upon infection, is a positive defence regulator. Overexpression of ZmNF-YA13 enhanced resistance, whereas knockout mutants were more susceptible. Integrated multi-omics analysis further revealed that ZmNF-YA13 activates the flavonoid biosynthesis pathway, promoting the accumulation of antimicrobial compounds like gallocatechin, quercetin and chalcone. Collectively, our work establishes the ZmWRKY92-miR169s-ZmNF-YA13-flavonoid module as a key signalling pathway in maize antifungal immunity, providing novel targets for maize disease resistance improvement.
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