ArticleGut pathogens2026
The association between Helicobacter pylori and osteoporosis: the mediating effect of inflammation.
Article in Gut pathogens, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOsteoporosis, a widespread metabolic bone disorder, leads to diminished bone density, heightened susceptibility to fractures, and overall skeletal fragility. As the world's population continues to age, this condition has emerged as a pressing public health issue. Recent research has explored the possible link between Helicobacter pylori (H. pylori) infection and various systemic diseases beyond the stomach. Yet, the connection between H. pylori and osteoporosis remains hotly debated, with the exact biological mechanisms still unclear.
methodsThe study recruited participants from Taizhou Hospital who underwent routine health evaluations, including hematological assessment, urea breath tests, and bone density evaluations using dual-energy X-ray absorptiometry. Logistic regression models were used to investigate the relationship between H. pylori infection and osteoporosis. Additionally, mediation analysis was performed to determine the potential mediating role of inflammation in this association.
resultsLogistic regression analysis identified H. pylori infection as a risk factor for osteoporosis. A subsequent cohort study provided additional evidence that chronic H. pylori infection is associated with an increased risk of osteoporosis. Mediation analysis revealed that inflammatory responses partially mediate the association between H. pylori and osteoporosis.
conclusionThis study suggests that H. pylori infection may be associated with an elevated risk of osteoporosis in postmenopausal women, with inflammatory response potentially acting as a partial mediating pathway.
Indexed as
Identifiers
41792791What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.