Evidence map›Paper›PMID 41792738›Full record

ArticleJournal of nanobiotechnology2026

Selenium nanoparticles with bioorthogonal targeting to boost CAR-cell therapy for colorectal cancer.

Jinfan Zhou, Gaohua Li, Yunze Xu, Wenhui Ma, Xuehua Zhang, Haitao Yuan, Zilin Tan, Zhenghao Li, Hongwei Yu, Zhenzhao Xu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jinfan Zhou *Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Gaohua Li *Department of Retroperitoneal Tumor Surgery, Peking University People's Hospital, Beijng, 100044, China.
Yunze Xu *Institute of Biomaterials and Tissue Engineering & Fujian Provincial Key Laboratory of Biochemical Technology, Huaqiao University, Xiamen, 361021, China.
Wenhui MaGuangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Xuehua ZhangGuangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Haitao YuanGuangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Zilin TanGuangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Zhenghao LiGuangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Hongwei YuInstitute of Biomaterials and Tissue Engineering & Fujian Provincial Key Laboratory of Biochemical Technology, Huaqiao University, Xiamen, 361021, China.
Zhenzhao XuGuangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Zhiqiang YuDepartment of Laboratory Medicine, Dongguan Key Laboratory of Precision Diagnosis and Treatment for Tumors, Dongguan Institute of Clinical Cancer Research, The Tenth Affiliated Hospital of Southern Medical University, Dongguan People's Hospital), Dongguan, 523058, China. yuzq@smu.edu.cn.
Jiafei XiStem Cell and Regenerative Medicine Lab, Beijing Institute of Radiation Medicine, Beijing, 100850, China. xi_jiafei@126.com.
Chaoping FuInstitute of Biomaterials and Tissue Engineering & Fujian Provincial Key Laboratory of Biochemical Technology, Huaqiao University, Xiamen, 361021, China. fuchp@hqu.edu.cn.
Yanan WangGuangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. wyn8116@163.com.

Funding

Fundamental Research Funds for the Central Universities ZQN-1107Natural Science Foundation of Fujian Province 2022J01297Natural Science Foundation of Guangdong Province in China 2018A030313537Science and Technology Program of Guangzhou in China 107167815080
6 · The paper itself

Abstract

The treatment of solid tumors with chimeric antigen receptor natural killer (CAR-NK) cell therapy confronts significant barriers, notably poor cellular infiltration and a highly immunosuppressive tumor microenvironment (TME). To overcome these challenges, we developed selenium-containing polymer nanoparticles (ManNAl-SeNPs) loaded with dibenzocyclooctyne (DBCO)-modified mannose. Metabolic glycoengineering metabolic glycoengineering (MGE) enabled efficient labeling of exogenous DBCO on azide (N

Indexed as

Colorectal NeoplasmsImmunotherapy, AdoptiveNanoparticlesReceptors, Chimeric AntigenSeleniumAnimalsCell Line, TumorClick ChemistryHumansKiller Cells, NaturalMicePolymersTumor MicroenvironmentPolymersReceptors, Chimeric AntigenSeleniumBioorthogonal reactionCAR-NK cellsColorectal cancerSeNPs

Identifiers

PMID41792738
PMCPMC13077882

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.