ArticleBMC oral health2026
LINC00514 regulates oral squamous cell carcinoma progression and prognosis by targeting miR-195-5p.
Article in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeOral squamous cell carcinoma (OSCC) ranks as the most prevalent malignant tumor within the oral cavity. This research aims to investigate the potential function of LINC00514 in the prognosis and malignant progression of OSCC patients.
methodsThe study included 69 OSCC patients. LINC00514, miR-195-5p and MAPK8 expression in OSCC tissues and cells was determined using qRT-PCR. The prognostic value of LINC00514 was analyzed using Kaplan-Meier curves. The abilities of cells to proliferate, migrate, and invade were evaluated using CCK-8 and Transwell assays. MAPK8 protein levels were determined by Western blot. The regulatory mechanism was investigated by luciferase reporter assays and RIP experiments.
resultsIn OSCC tissues and cells, LINC00514 expression was elevated, miR-195-5p expression was reduced, and their expression exhibited a negative correlation. High LINC00514 expression was linked to a poor prognosis in OSCC patients. Silencing LINC00514 suppressed the proliferation, migration, and invasion of cells. miR-195-5p was a target miRNA of LINC00514. When miR-195-5p was inhibited, the suppression of cell proliferation, migration, and invasion caused by siRNA-LINC00514 was partially reversed. MAPK8 was a target mRNA of miR-195-5p. Overexpression of MAPK8 rescued the suppressed proliferation, migration, and invasion of cells caused by miR-195-5p upregulation.
conclusionLINC00514 exhibits high expression in OSCC and is linked to poor prognostic outcomes in patients. It modulates the malignant biological behavior of OSCC cells by targeting miR-195-5p. LINC00514 might serve as a potential prognostic biomarker and therapeutic target for OSCC.
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