Evidence map›Paper›PMID 41792681›Full record

ArticleBMC oral health2026

Calcium phosphate polymer induced liquid precursor improves dentin bonding performance of primary teeth with dentinogenesis imperfecta type II.

Aochen Wang, Xin Liu, Yan Wang, Xin Li, Jinghui Yang, Ruikang Tang, Zhuo Chen, Guobin Yang, Xu Chen, Zhi Chen and 1 more

Abstract read
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In one paragraph

Article in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Aochen Wang *The State Key Laboratory Breeding Base of Basic Science of Stomatology and Key Laboratory for Oral Biomedicine of Ministry of Education, School and Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University, Wuhan, China.
Xin Liu *The State Key Laboratory Breeding Base of Basic Science of Stomatology and Key Laboratory for Oral Biomedicine of Ministry of Education, School and Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University, Wuhan, China.
Yan WangThe State Key Laboratory Breeding Base of Basic Science of Stomatology and Key Laboratory for Oral Biomedicine of Ministry of Education, School and Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University, Wuhan, China.
Xin LiDivision of Restorative Dental Sciences, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China.
Jinghui YangThe State Key Laboratory Breeding Base of Basic Science of Stomatology and Key Laboratory for Oral Biomedicine of Ministry of Education, School and Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University, Wuhan, China.
Ruikang TangDepartment of Chemistry, Zhejiang University, Hangzhou, China.
Zhuo ChenStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Hangzhou, China.
Guobin YangThe State Key Laboratory Breeding Base of Basic Science of Stomatology and Key Laboratory for Oral Biomedicine of Ministry of Education, School and Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University, Wuhan, China.
Xu ChenDepartment of Paediatric Dentistry, School and Hospital of Stomatology, China Medical University, Shenyang, China.
Zhi ChenThe State Key Laboratory Breeding Base of Basic Science of Stomatology and Key Laboratory for Oral Biomedicine of Ministry of Education, School and Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University, Wuhan, China. zhichen@whu.edu.cn.
Guohua YuanThe State Key Laboratory Breeding Base of Basic Science of Stomatology and Key Laboratory for Oral Biomedicine of Ministry of Education, School and Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University, Wuhan, China. yuanguohua@whu.edu.cn.

Funding

Department of Science and Technology of Liaoning Province 2022-MS-214Fundamental Research Funds for the Central Universities 2042022dx0003National Natural Science Foundation of China 81570942National Natural Science Foundation of China 82201076National Natural Science Foundation of China 82370913National Natural Science Foundation of China Key Program 82230029Shenyang Municipal Bureau of Science and Technology RC230821
6 · The paper itself

Abstract

objectivesThe current study aims to assess the dentin bonding performance of primary molars with dentinogenesis imperfecta type II (DGI-II). Moreover, we assess the efficacy of calcium phosphate polymer induced liquid precursor (Ca/P-PILP), a biomimetic remineralization material, in improving the resin bonding performance of DGI-II dentin. MATERIALS AND

methodsDentin specimens from normal and DGI-II primary molars were treated with either Ca/P-PILP or double-distilled water. Morphology of these dentin specimens were observed using scanning electron microscopy (SEM), and the calcium and phosphorus contents were determined by energy-dispersive X-ray spectroscopy (EDS). Micro-tensile bond strength (µTBS) analysis was conducted to evaluate the resin bonding strength of dentin.

resultsSEM results showed that compared with normal dentin, DGI-II dentin exhibited significantly fewer dentinal tubules with nearly no intact tubular structures. Meanwhile, the dentin collagen fibers exhibited disorganized arrangement and compromised structural integrity. Compared with normal dentin, DGI-II dentin displayed inferior bonding performance with resin as shown by µTBS analysis, and EDS analyses showed that DGI-II dentin contained lower calcium and phosphorus contents. After treatment with Ca/P-PILP, the calcium and phosphorus contents of DGI-II dentin were significantly increased as shown by EDS analyses, and µTBS analysis showed that the bonding performance of DGI-II dentin was improved, while no notable effect was observed in normal dentin.

conclusionsPrimary molars with DGI-II display structural defects and reduced calcium and phosphorus contents in dentin. The reduced mineral contents are partially responsible for the compromised bonding performance of DGI-II dentin, for Ca/P-PILP which effectively enhances the mineral contents of DGI-II dentin improves the resin bonding performance of DGI-II dentin.

Indexed as

Calcium PhosphatesDental BondingDentinDentin-Bonding AgentsDentinogenesis ImperfectaPolymersTooth, DeciduousCalciumHumansMicroscopy, Electron, ScanningMolarSpectrometry, X-Ray EmissionTensile StrengthCalciumcalcium phosphateCalcium PhosphatesDentin-Bonding AgentsPolymersCalcium phosphate polymer-induced liquid precursorDental adhesiveDentine bondingDentinogenesis imperfecta type IIMicro-tensile bond strength

Identifiers

PMID41792681
PMCPMC13081329

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.