Evidence map›Paper›PMID 41792528›Full record

ReviewActa neurologica Belgica2026

High prevalence of posttraumatic stress disorder in survivors of aneurysmal subarachnoid hemorrhage: a 6-month follow-up screening study.

Isabela Costola Windlin, Bruno Braga Sisnando da Costa, Pedro Henrique Mouty Rabello, Ilan David Friedmann, Yan Luca de Abreu Alves Jacinto, Davi Jorge Fontoura Solla, Carlos Gilberto Carlotti, Eberval Gadelha Figueiredo

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In one paragraph

Review in Acta neurologica Belgica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03569540 (Glibenclamide in Aneurysmatic Subarachnoid Hemorrhage), which is not on this map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03569540 phase4unknown statusnot on this map

Glibenclamide in Aneurysmatic Subarachnoid Hemorrhage: A Prospective and Randomized Study

TypeinterventionalSponsorUniversity of Sao Paulo General HospitalRan2018 to 2019Enrolled50ConditionsSubarachnoid Hemorrhage, AneurysmalArmsGlibenclamide, Placebo
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Isabela Costola WindlinDepartment of Neurosurgery, University of São Paulo, São Paulo, Brazil.
Bruno Braga Sisnando da CostaDepartment of Neurosurgery, University of São Paulo, São Paulo, Brazil.
Pedro Henrique Mouty RabelloDepartment of Neurosurgery, University of São Paulo, São Paulo, Brazil.
Ilan David FriedmannDepartment of Neurosurgery, University of São Paulo, São Paulo, Brazil.
Yan Luca de Abreu Alves JacintoDepartment of Neurosurgery, University of São Paulo, São Paulo, Brazil.
Davi Jorge Fontoura SollaDepartment of Neurosurgery, University of São Paulo, São Paulo, Brazil.
Carlos Gilberto CarlottiDepartment of Neurosurgery, University of São Paulo, São Paulo, Brazil.
Eberval Gadelha FigueiredoDepartment of Neurosurgery, University of São Paulo, São Paulo, Brazil. ebgadelha@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPosttraumatic stress disorder (PTSD) is increasingly recognized as a sequela of subarachnoid hemorrhage (SAH); however, its prevalence and clinical correlates remain understudied. This study assessed the prevalence of PTSD symptoms and associated psychological symptoms among survivors of SAH.

methodsA 6-month prospective analysis of 45 SAH survivors from the GASH trial (NCT03569540) was conducted. PTSD symptoms were evaluated using the Screen for Posttraumatic Stress Symptoms (SPTSS), with concurrent assessment of anxiety/depression (Hospital Anxiety and Depression Scale, HADS) and functional outcomes (modified Rankin Scale).

resultsAt six months post-SAH, 55,56% (n = 25) of patients met the SPTSS criteria for significant PTSD symptoms. Avoidance (mean score: 23,36 ± 11,75) and hyperarousal (19,52 ± 10,22) were the most prominent symptoms. PTSD was strongly associated with concurrent anxiety (HADS-A ≥ 7; p < 0.001) and depression (HADS-D ≥ 6; p < 0.001).

conclusionNearly half of SAH survivors screened positive for PTSD-related symptoms within six months, with avoidance behaviors predominating. The high comorbidity of anxiety and depression underscores the necessity for integrated neuropsychiatric care in SAH follow-up protocols.

Indexed as

AnxietyDepressionNeuropsychiatric outcomesPosttraumatic stress disorderSubarachnoid hemorrhage

Identifiers

PMID41792528

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Registered trials

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