Evidence map›Paper›PMID 41792526›Full record

ReviewCurrent urology reports2026

Sarcomatoid Renal Cell Carcinoma: Biological Features and Therapeutic Implications-A Narrative Review.

Francesco Lasorsa, Martina Milella, Monica Rutigliano, Antonio di Bari, Antonio d'Amati, Savio Domenico Pandolfo, Gabriele Bignante, Alessandro Caniglia, Riccardo Autorino, Pasquale Ditonno and 1 more

Abstract readReview
In one paragraph

Review in Current urology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Francesco LasorsaDepartment of Precision and Regenerative Medicine and Ionian Area, Urology and Kidney Transplantation Unit, University of Bari "Aldo Moro", Bari, Italy. francesco-lasorsa96@libero.it.ORCID http://orcid.org/0000-0001-8884-0757
Martina MilellaDepartment of Precision and Regenerative Medicine and Ionian Area, Urology and Kidney Transplantation Unit, University of Bari "Aldo Moro", Bari, Italy.
Monica RutiglianoDepartment of Precision and Regenerative Medicine and Ionian Area, Urology and Kidney Transplantation Unit, University of Bari "Aldo Moro", Bari, Italy.
Antonio di BariDepartment of Precision and Regenerative Medicine and Ionian Area, Urology and Kidney Transplantation Unit, University of Bari "Aldo Moro", Bari, Italy.
Antonio d'AmatiAnatomical Pathology Unit, Fondazione Policlinico Universitario ″A. Gemelli″ IRCCS, Università Cattolica S. Cuore, Rome, 00168, Italy.
Savio Domenico PandolfoDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, Naples, Italy.
Gabriele BignanteDivision of Urology, Department of Oncology, University of Turin, San Luigi Gonzaga Hospital, Orbassano, Turin, Italy.
Alessandro CanigliaPathology Unit, IRCCS Istituto Tumori "Giovanni Paolo II", Bari, 70124, Italy.
Riccardo AutorinoDepartment of Urology, Cleveland Clinic, Cleveland, OH, USA.
Pasquale DitonnoDepartment of Precision and Regenerative Medicine and Ionian Area, Urology and Kidney Transplantation Unit, University of Bari "Aldo Moro", Bari, Italy.
Giuseppe LucarelliDepartment of Precision and Regenerative Medicine and Ionian Area, Urology and Kidney Transplantation Unit, University of Bari "Aldo Moro", Bari, Italy. giuseppe.lucarelli@uniba.it.ORCID http://orcid.org/0000-0001-7807-1229

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of the reviewThis review underscores the importance of recognizing sarcomatoid features in renal cell carcinoma, as this component significantly impacts prognosis and treatment strategies. RECENT

findingsSarcomatoid renal cell carcinoma (sRCC) is a rare and aggressive form of renal cancer characterized by poor prognosis and distinct biological features. Despite its clinical significance, there remains a knowledge gap regarding the comprehensive understanding of its molecular and therapeutic landscape. Recent studies provided an extensive overview of the clinical, pathological, and molecular characteristics of sRCC, highlighting its unique genomic alterations and immune profile. Notably, sRCC exhibits a highly inflamed tumor microenvironment, which correlates with increased responsiveness to immune checkpoint inhibitors. Our findings suggest that integrating immunotherapy into the management of sRCC could enhance patient outcomes, paving the way for future research and clinical applications in this challenging cancer subtype.

Indexed as

Carcinoma, Renal CellKidney NeoplasmsHumansPrognosisTumor MicroenvironmentMetabolismPathologyRenal cell carcinomaSarcomatoidTreatment

Identifiers

PMID41792526
PMCPMC12966250

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.