Evidence map›Paper›PMID 41792482›Full record

ArticleMikrochimica acta2026

A plug-and-play surface acoustic wave-based SERS chip for rapid enrichment and ultrasensitive detection of tumor exosomes.

Tingyu Wang, Zefan Xu, Lei Wu, Yu Zhang, Hang Liu, Zuyao Wang, Shenfei Zong, Kuo Yang, Hong Wang, Zhuyuan Wang

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tingyu WangAdvanced Photonics Center, School of Electronic Science and Engineering, Southeast University, Nanjing, 210096, China.
Zefan XuAdvanced Photonics Center, School of Electronic Science and Engineering, Southeast University, Nanjing, 210096, China.
Lei WuAdvanced Photonics Center, School of Electronic Science and Engineering, Southeast University, Nanjing, 210096, China. lwu@seu.edu.cn.
Yu ZhangAdvanced Photonics Center, School of Electronic Science and Engineering, Southeast University, Nanjing, 210096, China.
Hang LiuAdvanced Photonics Center, School of Electronic Science and Engineering, Southeast University, Nanjing, 210096, China.
Zuyao WangAdvanced Photonics Center, School of Electronic Science and Engineering, Southeast University, Nanjing, 210096, China.
Shenfei ZongAdvanced Photonics Center, School of Electronic Science and Engineering, Southeast University, Nanjing, 210096, China.
Kuo YangAdvanced Photonics Center, School of Electronic Science and Engineering, Southeast University, Nanjing, 210096, China.
Hong WangDepartment of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, China.
Zhuyuan WangAdvanced Photonics Center, School of Electronic Science and Engineering, Southeast University, Nanjing, 210096, China. wangzy@seu.edu.cn.

Funding

the Fundamental Research Funds for the Central Universities 2242025F10007the National Natural Science Foundation of China 62205027the National Natural Science Foundation of China 62205053the National Natural Science Foundation of China 62305054the Southeast University Interdisciplinary Research Program for Young Scholars 2024FGC1007
6 · The paper itself

Abstract

Exosomes hold considerable promise for early cancer diagnosis. However, their low abundance during early tumor progression and inefficient receptor binding remain obstacles to their broad application. Here, we present the surface acoustic wave (SAW)-SERS Exosome Capture Analysis Chip (SEC-chip), which enriches exosomes within 5 min and quantifies HER2 using only 5 µL of serum. The device features a reusable acoustic transducer coupled with a disposable, CD63 aptamer functionalized capture base. Acoustic microstreaming concentrates vesicles into the detection zone, enabling a detection limit of 5 particles/5 µL, representing a 100-fold improvement over static assays. This hybrid design eliminates cross-contamination and reduces costs. Validated on 12 clinical samples, the SEC-chip accurately stratified HER2-positive breast cancer patients. Integrating rapid processing with ultrasensitivity, the platform offers a robust liquid biopsy tool for tumor diagnosis and future point-of-care screening.

Indexed as

Breast NeoplasmsExosomesSpectrum Analysis, RamanAcousticsAptamers, NucleotideErb-b2 Receptor Tyrosine KinasesFemaleHumansLimit of DetectionSoundTetraspanin 30Aptamers, NucleotideERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesTetraspanin 30Breast cancerExosomePOCTSERSSurface acoustic wave

Identifiers

PMID41792482

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.