Evidence map›Paper›PMID 41792411›Full record

Observational studyCancer reports (Hoboken, N.J.)2026

Increased Infiltration of CD4

Goro Takahashi, Seiichi Shinji, Toshiyuki Ishiwata, Takeshi Yamada, Kay Uehara, Akihisa Matsuda, Tomio Arai, Ryuji Ohashi, Yasuyuki Yokoyama, Takuma Iwai and 1 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Cancer reports (Hoboken, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Goro TakahashiDepartment of Gastroenterological Surgery, Nippon Medical School, Tokyo, Japan.ORCID 0000-0002-8561-8349
Seiichi ShinjiDepartment of Gastroenterological Surgery, Nippon Medical School, Tokyo, Japan.ORCID 0000-0002-9204-6393
Toshiyuki IshiwataDivision of Aging and Carcinogenesis, Research Team for Geriatric Pathology, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.ORCID 0000-0002-4180-0069
Takeshi YamadaDepartment of Gastroenterological Surgery, Nippon Medical School, Tokyo, Japan.ORCID 0000-0002-1436-7482
Kay UeharaDepartment of Gastroenterological Surgery, Nippon Medical School, Tokyo, Japan.ORCID 0000-0001-9669-5860
Akihisa MatsudaDepartment of Gastroenterological Surgery, Nippon Medical School, Tokyo, Japan.ORCID 0000-0002-6468-9375
Tomio AraiDepartment of Pathology, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.ORCID 0000-0003-4583-8301
Ryuji OhashiDepartment of Diagnostic Pathology, Nippon Medical School, Tokyo, Japan.ORCID 0000-0001-7053-038X
Yasuyuki YokoyamaDepartment of Gastroenterological Surgery, Nippon Medical School, Tokyo, Japan.ORCID 0009-0002-6343-7982
Takuma IwaiDepartment of Gastroenterological Surgery, Nippon Medical School, Tokyo, Japan.ORCID 0000-0002-4706-1228
Hiroshi YoshidaDepartment of Gastroenterological Surgery, Nippon Medical School, Tokyo, Japan.ORCID 0000-0002-2463-9023

Funding

Ministry of Education, Culture, Sports, Science, and Technology, Japan 19K18165Ministry of Education, Culture, Sports, Science, and Technology, Japan 22K08835
6 · The paper itself

Abstract

backgroundObstructive colorectal cancer (OCRC) presents as an oncologic emergency with poor prognosis. Although tumor-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs) are known to affect colorectal cancer outcomes, their roles in OCRC remain unclear. METHODS AND

resultsWe retrospectively analyzed 66 patients with Stages II-III OCRC who underwent curative resection following endoscopic decompression. CD4

conclusionsHigh immune cell infiltration at the invasive front was associated with favorable prognosis, even in OCRC. As the invasive front represents the interface between host and tumor, assessment of the tumor immune microenvironment at this site may refine risk stratification and optimize clinical management in OCRC patients.

Indexed as

CD4-Positive T-LymphocytesCD8-Positive T-LymphocytesColorectal NeoplasmsIntestinal ObstructionLymphocytes, Tumor-InfiltratingTumor-Associated MacrophagesAgedAntigens, CDAntigens, Differentiation, MyelomonocyticCD68 MoleculeFemaleHumansMaleMiddle AgedNeoplasm StagingPrognosisAntigens, CDAntigens, Differentiation, MyelomonocyticCD68 antigen, humanCD68 Moleculeimmunofluorescenceobstructive colorectal cancertumor‐associated macrophagestumor‐infiltrating lymphocytestumor microenvironment

Identifiers

PMID41792411
PMCPMC12965902

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.