ArticleVirus genes2026
Molecular characterization and genotypic diversity of human astroviruses among patients with gastroenteritis in Saudi Arabia, 2022-2023.
Article in Virus genes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Human astroviruses (HAstV) are a significant viral pathogen contributing to acute gastroenteritis. This study investigated the molecular diversity of human astroviruses in Riyadh, Saudi Arabia. A total of 1043 stool samples were collected from patients with acute gastroenteritis between July 2022 and June 2023 across five hospitals. Initial screening for HAstV was performed using real-time PCR, followed by PCR amplification and sequencing of the ORF1 capsid region for genotyping. HAstV was detected in 16 (1.53%) of the samples. Among the HAstV-positive cases, 8 patients (50%) were male and 8 (50%) were female. The highest detection rate was observed in the 0-18-year age group (12 cases, 75%). The highest number of infections were recorded in winter (10 cases, 62.5%), followed by autumn and spring (3 cases each, 18.75%). The circulation of two distinct HAstV genotypes, HAstV-1 (93.75%) and HAstV-5 (6.25%), was recorded. Maximum-likelihood phylogenetic reconstruction confirmed the placement of 12 sequences within the HAstV-1 clade, showing low intra-clade divergence. The clear separation of genotypes may underscore the ongoing genetic diversification of HAstV in the region. These findings highlight the importance of molecular surveillance for detecting emerging and circulating genotypes that may influence transmission dynamics or clinical impact.
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