ReviewJournal of the Association for Research in Otolaryngology : JARO2026
The Cochlear Lateral Wall as a Biological Battery: the Mechanisms Underlying K
Review in Journal of the Association for Research in Otolaryngology : JARO, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Structural and Molecular Evidence for a Frequency-Dependent Electrochemical Gradient in the Human Cochlear Lateral Wall.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The cochlea possesses an exceptional capacity for rapid sensory transduction, enabling sound perception of at frequencies exceeding 15 kHz. This extraordinary performance depends on a specialized electrochemical environment that maintains a high endocochlear potential (EP) and facilitates efficient K⁺ circulation. The cochlear lateral wall serves as a central component, functioning as a biological battery that generates and sustains the EP via intricate ion transport mechanisms. It consists of two epithelial-like layers-the marginal cell layer and the syncytial layer-which are electrically insulated by tight junctions and interconnected via gap junctions. K⁺ enters hair cells from the K⁺-rich endolymph to initiate sensory transduction and is subsequently recycled through the perilymph and reabsorbed by the lateral wall. Our combined electrophysiological and mathematical modeling studies elucidate that the EP primarily depends on K⁺ equilibrium potentials across the apical membranes of intermediate and marginal cells, primarily mediated by K
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.