Evidence map›Paper›PMID 41792328›Full record

ReviewNature aging2026

Dietary restriction in aging and longevity.

Tomas Schmauck-Medina, Sofie Lautrup, Andrea Di Francesco, Sarah J Mitchell, Christoffer Clemmensen, Linda Partridge, George S Roth, Rozalyn M Anderson, Julie A Mattison, Rafael de Cabo and 6 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. A simplified intermittent fasting regimen robustly extendsbioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Longevity inbioRxiv : the preprint server for biology · 2026
    Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Tomas Schmauck-MedinaDepartment of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway.ORCID http://orcid.org/0000-0003-4618-0628
Sofie LautrupDepartment of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway.
Andrea Di FrancescoCalico Life Sciences, South San Francisco, CA, USA.
Sarah J MitchellLudwig Princeton Branch, Ludwig Institute for Cancer Research, Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0000-0002-4027-3754
Christoffer ClemmensenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Linda PartridgeInstitute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, London, UK.
George S RothGeroScience and Prolongevity Technologies, Pylesville, MD, USA.
Rozalyn M AndersonDepartment of Medicine, SMPH, University of Wisconsin, Madison, WI, USA.ORCID http://orcid.org/0000-0002-0864-7998
Julie A MattisonTranslational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Rafael de CaboTranslational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-2830-5693
John R SpeakmanShenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.ORCID http://orcid.org/0000-0002-2457-1823
Arlan RichardsonOklahoma City VA Medical Center, Oklahoma City, OK, USA.
Donald K IngramPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA.
Richard WeindruchUniversity of Wisconsin, Madison, WI, USA.
Mark P MattsonDepartment of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA. mmattso2@jhmi.edu.ORCID http://orcid.org/0009-0000-5542-5565
Evandro F FangDepartment of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway. e.f.fang@medisin.uio.no.ORCID http://orcid.org/0000-0003-0355-7202

Funding

Molecular Networks in Aging and Caloric Restriction in Rhesus MonkeysR01AG074503 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Rozalyn M. Anderson · 2022 to 2026
$3.1M
NIA NIH HHS R01 AG074503
6 · The paper itself

Abstract

Different types of dietary restriction (DR) have been practiced by humans for religious and medical purposes for millennia, but only during the past three decades has the scientific study of DR at cellular and molecular levels proliferated. Here we review the evidence testing a variety of DR paradigms in the context of aging, focusing on mammalian findings. We discuss potential DR mimetics that modulate autophagy, FGF21, AMPK, mTORC1, NAD

Indexed as

AgingCaloric RestrictionLongevityAnimalsAutophagyHumansSignal Transduction

Identifiers

PMID41792328

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.