Evidence map›Paper›PMID 41792222›Full record

ArticleScientific reports2026

Estimated glucose disposal rate and cardiovascular risk in metabolically healthy adults: a nationwide prospective cohort study.

Wenbo Li, Fang Yuan, Cong Gao, Wenting Li, Qirui Guo, Xiaoling Liao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wenbo LiDepartment of Neurology, Beijing Tiantan hospital, Capital Medical University, Beijing, 100070, China.
Fang YuanZibo Infectious Disease Hospital, Zibo, 255051, Shandong Province, China.
Cong GaoDepartment of Neurology, Beijing Tiantan hospital, Capital Medical University, Beijing, 100070, China.
Wenting LiDepartment of Neurology, Beijing Tiantan hospital, Capital Medical University, Beijing, 100070, China.
Qirui GuoPeking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100730, China.
Xiaoling LiaoDepartment of Neurology, Beijing Tiantan hospital, Capital Medical University, Beijing, 100070, China. xiaolingliao@ncrcnd.org.cn.

Funding

National Key Research and Development Program of China NO. 2022YFE0209600
6 · The paper itself

Abstract

To investigate the association of estimated glucose disposal rate (eGDR) with CVD, including stroke and heart disease, in metabolically healthy adults. All data were drawn from the China Health and Retirement Longitudinal Study, including participants aged ≥ 45 years who were free of metabolic syndrome (MetS) at baseline. Participants were enrolled in 2015 and followed up in 2018 and 2020. The association between eGDR and CVD was evaluated using multivariable Cox regression models and restricted cubic spline (RCS). Among the 4999 participants, the median age was 61 (IQR: 55-68) years, and 2838 (56.77%) were female. During the 5-year follow-up, 885 (17.70%) individuals experienced incident CVD events, comprising 322 (6.44%) cases of stroke and 653 (13.06%) of heart disease. After adjustment for other covariates, higher eGDR levels were independently associated with lower risks of CVD (HR = 0.47, 95% CI 0.37-0.61), stroke (HR = 0.39, 95% CI 0.25-0.61), and heart disease (HR = 0.51, 95% CI 0.38-0.68). RCS analysis indicated a significant linear association of eGDR with CVD and its subtypes (all P for nonlinearity > 0.05). Higher levels of eGDR were significantly associated with a decreased risk of CVD and its subtypes in metabolically healthy individuals.

Indexed as

Blood GlucoseCardiovascular DiseasesGlucoseAgedChinaFemaleHumansLongitudinal StudiesMaleMetabolic SyndromeMiddle AgedProspective StudiesRisk FactorsBlood GlucoseGlucoseCardiovascular diseaseEstimated glucose disposal rateInsulin resistanceMetabolic health

Identifiers

PMID41792222
PMCPMC13083968

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.