In one paragraphObservational study in European stroke journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01934725 (Searching for Explanations for Cryptogenic Stroke in the Young), which is not on this map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Searching for Explanations for Cryptogenic Stroke in the Young: Revealing the Etiology, Triggers, and Outcome (SECRETO)
TypeobservationalSponsorSECRETO Study ConsortiumRan2013 to 2031Enrolled1,200ConditionsBrain Infarction, Ischemic Stroke, Thrombosis, Foramen Ovale, Patent
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
35 authors.
Maximilian C SihvoHelsinki University Central Hospital and University of Helsinki, Helsinki, Finland.ORCID 0009-0008-0731-8296 Marialuisa ZeddeNeurology Unit, Stroke Unit, Azienda Unità Sanitaria Locale, IRCCS Reggio Emilia, Italy.ORCID 0000-0001-7530-818X Tomi SarkanenDepartment of Neurology, Tampere University Hospital, Wellbeing Services County of Pirkanmaa and Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.ORCID 0000-0001-8815-2807 Dalius JatužisDepartment of Neurology and Neurosurgery, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.ORCID 0000-0001-6159-4795 Kristina RyliškienėDepartment of Neurology and Neurosurgery, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.ORCID 0000-0001-9596-1733 Radim LicenikAcute Stroke Centre, North West Anglia NHS Foundation Trust, Peterborough City Hospital, Peterborough, United Kingdom.ORCID 0000-0002-9145-4598 Phillip FerdinandNeurosciences, University Hospitals of North Midlands NHS Trust, Stoke-on-Trent, United Kingdom.ORCID 0000-0002-8715-2917 Ana Catarina FonsecaHospital Santa Maria, Faculty of Medicine, University of Lisbon, Lisbon, Portugal.ORCID 0000-0001-6913-5526 Patricia Martínez-SánchezDepartment of Neurology, Torrecardenas University Hospital, University of Almería, Almería, Spain.ORCID 0000-0003-1945-4435 Petra RedforsDepartment of Neurology, Sahlgrenska University Hospital and Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.ORCID 0000-0001-5956-4255 Katarina JoodDepartment of Neurology, Sahlgrenska University Hospital and Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.ORCID 0000-0001-8746-1771 Juha HuhtakangasDepartment of Neurology, Oulu University Hospital and University of Oulu, Oulu, Finland.ORCID 0000-0001-7143-519X Pekka JäkäläNeurocenter Neurology, Kuopio University Hospital, Finland and University of Eastern Finland, Kuopio, Finland.ORCID 0000-0002-8410-6915 Hugo Ten CateDepartment of Internal Medicine, and Thrombosis Expert Center, Maastricht University Medical Center and CARIM school for cardiovascular diseases, Maastricht, The Netherlands.ORCID 0000-0001-7796-4463 Eva GerdtsCenter for Research on Cardiac Disease in Women, Department of Clinical Science, University of Bergen, Bergen, Norway.ORCID 0000-0003-4109-2311 Mika LehtoDepartment of Cardiology, Heart and Lung Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.ORCID 0000-0002-8691-5142 Juha SinisaloDepartment of Cardiology, Heart and Lung Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.ORCID 0000-0002-0169-5137 Steven J KittnerDepartment of Neurology, University of Maryland School of Medicine, Baltimore, MD, United States.ORCID 0000-0002-8457-8744 Braxton D MitchellDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, United States.ORCID 0000-0003-4920-4744 Funding
Academy of Finland 286246Academy of Finland 318075Academy of Finland 322656Helsinki and Uusimaa Hospital District research fund TYH2014407Helsinki and Uusimaa Hospital District research fund TYH2018318Sahlgrenska University Hospital ALFGBG-726821
6 · The paper itselfAbstract
backgroundFamilial aggregation of stroke is well-documented, yet few studies have examined associations between stroke subtypes-particularly early-onset cryptogenic ischaemic stroke (eCIS)-and broader family history (FH) of cardiovascular disease. Such associations may provide insights into underlying etiologic mechanisms.
methodsIn this multicentre case-control study, we included eCIS patients aged 18-49 years and matched stroke-free controls. We analysed the association between FH of stroke, venous thromboembolism (VTE), coronary artery disease (CAD), aneurysms and eCIS using multivariable logistic regression, with a subgroup analysis stratifying patients by high-risk patent foramen ovale (HR-PFO).
resultsWe enrolled 508 eCIS patients (182 [36%] with HR-PFO) and 520 controls. Compared with controls, patients more frequently reported FH of stroke among first-degree relatives (FDR) (20% vs. 14%, P = .01) and grandparents (47% vs. 39%, P = .01), FH of early-onset stroke among FDR (5% vs. 2%, P = .01) and FH of early-onset VTE among FDR (5% vs. 2%, P = .003). In adjusted analyses, eCIS was associated with FH of stroke among FDR (OR 1.50; 95% CI, 1.04-2.16) and grandparents (1.50; 1.12-1.99), with FH of early-onset stroke among FDR (2.36; 1.11-5.04); and with FH of early-onset VTE among FDR (3.45; 1.47-8.13). eCIS was also associated with FH of VTE among FDR (1.80, 1.09-2.98) in the presence of HR-PFO. FH of CAD or aneurysms was not associated with eCIS.
conclusionFH of stroke and VTE, particularly early-onset events and in the presence of HR-PFO, are associated with eCIS. These findings support familial predisposition and highlight prothrombotic mechanisms in eCIS. CLINICAL
trial registrationwww.clinicaltrials.gov/study/NCT01934725.
Indexed as
Brain IschemiaCardiovascular DiseasesIschemic StrokeStrokeAdolescentAdultAge of OnsetCase-Control StudiesFemaleForamen Ovale, PatentGenetic Predisposition to DiseaseHumansMaleMiddle AgedRisk FactorsVenous Thromboembolismcryptogenicfamily historyischaemic strokePFOyoung stroke
Identifiers
PMID41792039
PMCPMC12965808
What OpenQuestion holds
Textmetadata
LicenceCC BY
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