ArticleAging cell2026
Physical Fitness Dynamics Shape Immune Remodeling in Healthy Aging: A 3-Year Longitudinal Study.
Article in Aging cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- CD8Immunity & ageing : I & A · 2026Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Aging is accompanied by functional decline and immune remodeling, yet the dynamics and early modifiability of these processes remain incompletely understood. Research suggests that lifestyle factors, particularly physical activity and fitness, influence immune aging. This study investigated longitudinal changes in physical performance and immune parameters in a well-characterized cohort of clinically healthy elderly. In this study, 49 clinically healthy elderly underwent repeated assessments of cardiorespiratory fitness, muscular strength, body composition, immune cell phenotypes, and serum cytokines at baseline, 1-year, and 3-year follow-up. We observed a shift toward an aged T cell profile, characterized by reductions in naïve and regulatory T cells (Tregs), alongside increases in differentiated and senescence-associated subsets. Treg subsets followed divergent trajectories, with resting Tregs (rTregs) declining and memory-like Tregs (mTregs) increasing. Serum levels of classical pro-inflammatory cytokines remained largely stable over the study period. Despite stable self-reported physical activity, participants showed declines in cardiorespiratory fitness and strength. Immune remodeling was primarily associated with declines in physical fitness, alongside an increase in highly differentiated CD4
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