Evidence map›Paper›PMID 41791866›Full record

ArticleGenes & development2026

A lncRNA drives developmentally timed decay of all members of an essential microRNA family.

Acadia L Grimme, Lu Li, Alyshia Scholl, Bridget F Donnelly, Neha Channamraju, Karl-Frédéric Vieux, Lecong Zhou, Geraldine Seydoux, Mingyi Xie, Katherine McJunkin

Abstract read
In one paragraph

Article in Genes & development, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Linking miRNAs to decay.Genes & development · 2026
    Article
  3. Article
  4. Article
  5. bioRxiv : the preprint server for biology · 2026
    Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Acadia L Grimme *National Institute of Diabetes and Digestive and Kidney Diseases Intramural Research Program, Bethesda, Maryland 20892, USA.
Lu Li *Department of Biochemistry, University of Florida, Gainesville, Florida 32603, USA.
Alyshia SchollDepartment of Molecular Biology and Genetics, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA.ORCID 0000-0001-5355-9383
Bridget F DonnellyNational Institute of Diabetes and Digestive and Kidney Diseases Intramural Research Program, Bethesda, Maryland 20892, USA.
Neha ChannamrajuNational Institute of Diabetes and Digestive and Kidney Diseases Intramural Research Program, Bethesda, Maryland 20892, USA.
Karl-Frédéric VieuxNational Institute of Diabetes and Digestive and Kidney Diseases Intramural Research Program, Bethesda, Maryland 20892, USA.
Lecong ZhouNational Institute of Diabetes and Digestive and Kidney Diseases Intramural Research Program, Bethesda, Maryland 20892, USA.
Geraldine SeydouxDepartment of Molecular Biology and Genetics, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA.ORCID 0000-0001-8257-0493
Mingyi XieDepartment of Biochemistry, University of Florida, Gainesville, Florida 32603, USA.ORCID 0000-0001-7955-197X
Katherine McJunkinNational Institute of Diabetes and Digestive and Kidney Diseases Intramural Research Program, Bethesda, Maryland 20892, USA; katherine.mcjunkin@nih.gov.

Funding

Biological functions and post-transcriptional regulation of microRNAsZIADK075147 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI MCJUNKIN, KATHERINE · 2018 to 2025
$14.4M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
RNA metabolism mediated by the Integrator complexR35GM128753 · NIGMS · UNIVERSITY OF FLORIDA · PI MINGYI XIE · 2018 to 2026
$4.0M
Regulation of Germ Cell Fate During EmbryogenesisR37HD037047 · NICHD · JOHNS HOPKINS UNIVERSITY · PI SEYDOUX, GERALDINE CATHERINE JOELLE · 2016 to 2025
$3.8M
Intramural NIH HHS ZIA DK075147NICHD NIH HHS R37 HD037047NIGMS NIH HHS R35 GM128753NIH HHS P40 OD010440
6 · The paper itself

Abstract

The spatiotemporal expression patterns of microRNAs (miRNAs) are crucial to their function. Target-directed miRNA degradation (TDMD) is an emerging regulatory module that contributes to these expression patterns wherein a specialized RNA (a TDMD trigger) drives miRNA decay through base pairing and the resulting recruitment of E3 ubiquitin ligase ZSWIM8/EBAX-1. Extensive base pairing to the miRNA seed region and 3' end has been proposed as a key feature that distinguishes TDMD triggers from conventional mRNA targets of miRNAs, which primarily pair with the seed. Here we identify the long noncoding RNA

Indexed as

Caenorhabditis elegansGene Expression Regulation, DevelopmentalMicroRNAsRNA, Long NoncodingRNA StabilityAnimalsBase PairingCaenorhabditis elegans ProteinsCaenorhabditis elegans ProteinsMicroRNAsRNA, Long NoncodingAgoArgonauteEBAX-1mir-35 familymiRISCRISCZSWIM8

Identifiers

PMID41791866
PMCPMC13115287

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.