Evidence map›Paper›PMID 41791865›Full record

ArticleGenes & development2026

Glc7/PP1 triggers Paf1 complex dissociation from RNA polymerase II to enable transcription termination.

Sanchirmaa Namjilsuren, Karen M Arndt

Abstract read
In one paragraph

Article in Genes & development, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Sanchirmaa NamjilsurenDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
Karen M ArndtDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA arndt@pitt.edu.ORCID 0000-0003-1320-9957

Funding

Mechanisms that Couple Chromatin Modifications to TranscriptionR35GM141964 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KAREN M ARNDT · 2021 to 2026
$2.8M
NIGMS NIH HHS R35 GM141964
6 · The paper itself

Abstract

The mechanisms that control the dynamic composition of RNAPII elongation complexes govern major transitions in the transcription cycle yet are poorly understood. Here, we show that the transcription elongation factor Spt5 determines elongation complex composition to promote productive elongation and the transition to termination. Using an unbiased genetic screen and genomic approaches in

Indexed as

Nuclear ProteinsProtein Phosphatase 1RNA Polymerase IISaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTranscription Termination, GeneticChromosomal Proteins, Non-HistoneGene Expression Regulation, FungalMutationPhosphorylationProtein BindingTranscriptional Elongation FactorsChromosomal Proteins, Non-HistoneGLC7 protein, S cerevisiaeNuclear ProteinsPAF1 protein, S cerevisiaeProtein Phosphatase 1RNA Polymerase IISaccharomyces cerevisiae ProteinsSPT5 transcriptional elongation factorTranscriptional Elongation FactorsGlc7Paf1PP1Spt5transcription elongationtranscription termination

Identifiers

PMID41791865
PMCPMC13078362

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.