ArticleBMJ open2026
Impact of disease burden on VO
Article in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo examine the association between spinal mobility, disease activity, frailty and cardiorespiratory fitness (maximal oxygen uptake (VO
methodsA cross-sectional comparative study was conducted at the University of Lahore and seven government hospitals (March-August 2025) including 74 patients with AS (40-55 years, modified New York criteria) and 77 age-matched and sex-matched healthy controls. Assessments included disease activity (Bath Ankylosing Spondylitis Disease Activity Index), functional limitation (Bath Ankylosing Spondylitis Functional Index), spinal mobility (Bath Ankylosing Spondylitis Metrology Index (BASMI)), chest expansion, frailty (Fatigue, Resistance, Ambulation, Illnesses, Loss of weight scale), pulmonary function and cardiorespiratory fitness (VO
resultsAmong 151 participants (74 AS, 77 controls), AS patients showed significantly reduced pulmonary function (forced expiratory volume in one second 83.5% vs 91.2%, forced vital capacity 85.1% vs 93.0%), lower VO
conclusionAS is associated with impaired pulmonary function, reduced spinal mobility and lower cardiorespiratory fitness, with disease activity, stiffness and restricted chest expansion potentially influencing physical activity and overall functional capacity.
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