Chronic activation of p38α in skeletal muscle causes necrotic changes, but also abolishes expression of MK2, MK3, and MKK6 and the muscle recovers.

Nechama Gilad, Ilona Darlyuk-Saadon, Manju Payini Mohanam, David Engelberg

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Article in The Journal of biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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4 authors.

Nechama GiladDepartment of Biological Chemistry, The Institute of Life Science, The Hebrew University of Jerusalem, Jerusalem, Israel; Singapore-HUJ Alliance for Research and Enterprise, Molecular Mechanisms of Liver Inflammatory Diseases (MLID) Program, National University of Singapore, Singapore.

Ilona Darlyuk-SaadonSingapore-HUJ Alliance for Research and Enterprise, Molecular Mechanisms of Liver Inflammatory Diseases (MLID) Program, National University of Singapore, Singapore; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Manju Payini MohanamSingapore-HUJ Alliance for Research and Enterprise, Molecular Mechanisms of Liver Inflammatory Diseases (MLID) Program, National University of Singapore, Singapore.

David EngelbergDepartment of Biological Chemistry, The Institute of Life Science, The Hebrew University of Jerusalem, Jerusalem, Israel; Singapore-HUJ Alliance for Research and Enterprise, Molecular Mechanisms of Liver Inflammatory Diseases (MLID) Program, National University of Singapore, Singapore; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address: engelber@mail.huji.ac.il.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The MAPK p38α is associated with skeletal muscle's development, differentiation and functionality. But, as it is overactive in muscle diseases and aging, it was proposed to be a pivotal promoter of these processes as well. It is not clear how p38α is involved in these disparate activities, in particular whether its chronic activation alone is sufficient to cause them. We established a mouse model designed to study the effects of p38α per se in skeletal muscle. p38α activation is achieved by inducible expression, in muscle, of an intrinsically active variant, p38α

Indexed as

Intracellular Signaling Peptides and ProteinsMAP Kinase Kinase 6Mitogen-Activated Protein Kinase 14Muscle, SkeletalProtein Serine-Threonine KinasesAnimalsMAP-Kinase-Activated Kinase 2MiceNecrosisIntracellular Signaling Peptides and ProteinsMap2k6 protein, mouseMAP-Kinase-Activated Kinase 2MAP-kinase-activated kinase 3MAP Kinase Kinase 6Mitogen-Activated Protein Kinase 14Protein Serine-Threonine KinasesC2C12 cellsMAPKMK2MK3MKK6p38αskeletal muscle

Identifiers

PMID41791712

DOI10.1016/j.jbc.2026.111338

PMCPMC13066812

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