Evidence map›Paper›PMID 41791667›Full record

ArticleJournal of thrombosis and haemostasis : JTH2026

Long-term mortality and causes of death after venous thromboembolism: findings from the Atherosclerosis Risk in Communities Cohort Study.

Debora Kamin Mukaz, Aixin Li, Weihua Guan, Rui Cao, Lingfeng Huo, Weihong Tang, Pamela L Lutsey, Neil A Zakai, Aaron R Folsom, Mary Cushman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thrombosis and haemostasis : JTH, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Debora Kamin MukazDepartment of Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont. Electronic address: debora.kamin-mukaz@med.uvm.edu.
Aixin LiDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minneapolis. Electronic address: https://x.com/Katheri05834954.
Weihua GuanDivision of Biostatistics, University of Minnesota, Minneapolis, Minneapolis.
Rui CaoDivision of Biostatistics, University of Minnesota, Minneapolis, Minneapolis.
Lingfeng HuoDivision of Biostatistics, University of Minnesota, Minneapolis, Minneapolis.
Weihong TangDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minneapolis.
Pamela L LutseyDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minneapolis.
Neil A ZakaiDepartment of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont.
Aaron R FolsomDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minneapolis.
Mary CushmanDepartment of Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont; Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont. Electronic address: https://x.com/MaryCushmanMD.

Funding

Vermont Center for Cardiovascular and Brain HealthP20GM135007 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Diego Adrianzen Herrera · 2020 to 2026
$17.4M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - COORDINATING CENTER - TASK AREA B.2 AND B.375N92022D00001 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID · 2022 to 2025
$13.7M
Epidemiology of Venous Thrombosis & Pulmonary EmbolismR01HL059367 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI TANG, WEIHONG · 1998 to 2024
$11.8M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00003 · NHLBI · UNIVERSITY OF MINNESOTA · PI LUTSEY, PAMELA L. · 2022 to 2025
$5.1M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00005 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI WAGENKNECHT, LYNNE E · 2022 to 2025
$5.0M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00004 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI WINDHAM, BEVERLY GWEN · 2022 to 2025
$4.8M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00002 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI CORESH, JOSEF · 2022 to 2025
$4.7M
Mentoring and Research in Patient-Oriented Cardiovascular PharmacoepidemiologyK24HL159246 · NHLBI · UNIVERSITY OF MINNESOTA · PI PAMELA L. Lutsey · 2021 to 2026
$644k
NHLBI NIH HHS 75N92022D00001NHLBI NIH HHS 75N92022D00002NHLBI NIH HHS 75N92022D00003NHLBI NIH HHS 75N92022D00004NHLBI NIH HHS 75N92022D00005NHLBI NIH HHS K24 HL159246NHLBI NIH HHS R01 HL059367NIGMS NIH HHS P20 GM135007
6 · The paper itself

Abstract

backgroundMore than 1 million people in the United States develop venous thromboembolism (VTE) annually, but little is known about long-term mortality and causes of death after VTE.

objectivesThe objective of this study was to investigate long-term mortality and causes of death after VTE, by VTE type.

methodsAtherosclerosis Risk in Communities cohort participants free of VTE at baseline were followed from 1987-1989 through 2019 for first-time VTE (unprovoked, cancer-provoked, or other provoked) and death. The hazard ratios (HRs) of death and the proportion who died for each cause of death after first VTE were estimated by VTE type.

resultsThe main causes of death after overall VTE were cancer (36%) and circulatory diseases (27%). After unprovoked VTE, 36% died of circulatory diseases and 13% of cancer. Those values were similar for other-provoked VTE. For cancer-provoked VTE, 80% died of cancer and 11% of circulatory diseases. Five years after overall VTE, the HR of death was 2.7 (95% CI: 2.6-3.0). This HR was highest for cancer-provoked VTE (HR, 5.5; 95% CI, 4.3-6.9). Those with unprovoked (HR, 1.9; 95% CI, 1.7-2.2) and other-provoked VTE (HR, 2.4; 95% CI, 2.0-2.7) also had elevated risk. Ten years after VTE, those with any VTE, unprovoked VTE, and other-provoked VTE had a 60% higher risk of death (95% CI for each 1.3-1.5 to 1.9).

conclusionsLong-term mortality risk after VTE in this United States cohort was higher than among people without VTE. Apart from those with cancer-provoked VTE, circulatory diseases were the primary cause of death after VTE.

Indexed as

AtherosclerosisVenous ThromboembolismAdultAgedCause of DeathFemaleHumansMaleMiddle AgedNeoplasmsProspective StudiesRisk AssessmentRisk FactorsTime FactorsUnited Statescause of deathmortalityvenous thromboembolism

Identifiers

PMID41791667
PMCPMC13177269

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.