Evidence map›Paper›PMID 41791290›Full record

ArticleRedox biology2026

Aryl hydrocarbon receptor in club cells drives Th17-mediated lung injury following inhalation exposure to environmentally persistent free radicals.

Rashmi Pathak, Avinash Kumar, Ashley Ferrier, David Burk, Stephania A Cormier

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rashmi PathakDepartment of Biological Sciences, Louisiana State University, Baton Rouge, LA, USA; Pennington Biomedical Research Center, Baton Rouge, LA, USA.
Avinash KumarDepartment of Biological Sciences, Louisiana State University, Baton Rouge, LA, USA; Pennington Biomedical Research Center, Baton Rouge, LA, USA.
Ashley FerrierDepartment of Biological Sciences, Louisiana State University, Baton Rouge, LA, USA; Pennington Biomedical Research Center, Baton Rouge, LA, USA.
David BurkDepartment of Biological Sciences, Louisiana State University, Baton Rouge, LA, USA; Pennington Biomedical Research Center, Baton Rouge, LA, USA.
Stephania A CormierDepartment of Biological Sciences, Louisiana State University, Baton Rouge, LA, USA; Pennington Biomedical Research Center, Baton Rouge, LA, USA. Electronic address: stephaniacormier@lsu.edu.

Funding

Role of microbiota in increased influenza severity due to particulate matter exposureP42ES013648 · NIEHS · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI MERCANTE, DONALD E · 2009 to 2024
$27.6M
The Role of IL4R Alpha in Neonatal RSV ImmunopathologyR01AI090059 · NIAID · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI CORMIER, STEPHANIA A · 2011 to 2025
$6.7M
NIAID NIH HHS R01 AI090059NIEHS NIH HHS P42 ES013648
6 · The paper itself

Abstract

Environmentally persistent free radicals (EPFRs), generated during thermal combustion processes including hazardous waste remediation, are emerging redox-active pollutants linked to adverse respiratory outcomes. EPFR inhalation induces neutrophilic asthma characterized by substantial lung injury. Neutrophilic asthma is driven by T helper 17 (Th17) cells which secrete IL-17. We identified aryl hydrocarbon receptor (AHR) as a key mediator of EPFR-induced pulmonary Th17 responses. Building on this, we discovered that club cells, specialized airway epithelial cells, are a primary site of AHR activation following EPFR exposure. To dissect the specific role of AHR in club cells, we generated mice with a conditional deletion of Ahr in club cells (AhrΔCC) by crossing Ahr

Indexed as

Basic Helix-Loop-Helix ProteinsInhalation ExposureLung InjuryReceptors, Aryl HydrocarbonTh17 CellsAnimalsDisease Models, AnimalFree RadicalsInterleukin-17LungMiceAhr protein, mouseBasic Helix-Loop-Helix ProteinsFree RadicalsInterleukin-17Receptors, Aryl HydrocarbonAryl hydrocarbon receptor (AHR)Club cellsEnvironmentally persistent free radicals (EPFRs)Neutrophilic asthmaOxidative stressRespiratory toxicology

Identifiers

PMID41791290
PMCPMC12972536

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.