Effects of Time-Restricted Eating on Ketone Metabolism and Immunoregulation in Premenopausal Women: Protocol for a Pilot, Prospective, Single-Arm Dietary Intervention Study.
Article in JMIR research protocols, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06169137 (Pilot Study of Isocaloric Time Restricted Eating on Ketone Metabolism and Immunoregulation), which is not on this map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pilot Study of Isocaloric Time Restricted Eating on Ketone Metabolism and Immunoregulation
TypeinterventionalSponsorNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Ran2024 to 2026Enrolled58ConditionsObesity, Body WeightArmsEarly Time-Restricted Eating, Conventional dietary regimen (12-hr, 9:30a-9:30p)
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
19 authors.
Geethika P Thota *Diabetes Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Rockville, MD, United States.ORCID 0000-0003-0438-8498
Natalie A Macheret *Diabetes Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Rockville, MD, United States.ORCID 0009-0000-5409-1567
Sophia B GlarosDiabetes Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Rockville, MD, United States.ORCID 0009-0008-6747-8048
Ila N Kacker *Diabetes Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Rockville, MD, United States.ORCID 0009-0004-3863-1892
Samson L Cantor *Diabetes Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Rockville, MD, United States.ORCID 0009-0004-6360-9996
Lilian Mabundo *Diabetes Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Rockville, MD, United States.ORCID 0009-0008-1591-0468
Noemi Malandrino *Diabetes Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Rockville, MD, United States.ORCID 0000-0001-5587-1127
Kong Y Chen *Diabetes Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Rockville, MD, United States.ORCID 0000-0002-0306-1904
Amber B Courville *Diabetes Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Rockville, MD, United States.ORCID 0000-0002-1419-3937
Sara Turner *Diabetes Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Rockville, MD, United States.ORCID 0009-0004-6679-8876
Shanna Yang *Diabetes Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Rockville, MD, United States.ORCID 0009-0003-3487-2632
Andrea Krenek *Diabetes Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Rockville, MD, United States.ORCID 0000-0002-2637-9616
Thomas C Recupero *Laboratory of Mitochondrial Biology and Metabolism, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, United States.ORCID 0009-0004-1202-4824
Rachael J Klein *Laboratory of Mitochondrial Biology and Metabolism, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, United States.ORCID 0000-0002-4289-0887
Kim Han *Laboratory of Mitochondrial Biology and Metabolism, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, United States.ORCID 0000-0001-9092-9881
Patrycja Puchalska *Clinical and Translational Science Institute, University of Minnesota, Minneapolis, MN, United States.ORCID 0000-0002-1875-1203
Peter Crawford *Clinical and Translational Science Institute, University of Minnesota, Minneapolis, MN, United States.ORCID 0000-0001-8597-4426
Michael N Sack *Laboratory of Mitochondrial Biology and Metabolism, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, United States.ORCID 0000-0002-3411-0000
Stephanie T Chung *Diabetes Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Rockville, MD, United States.ORCID 0000-0001-6989-0417
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itself
Abstract
backgroundIntermittent fasting interventions, such as time-restricted eating (TRE) without calorie restriction, may offer diverse cardiometabolic health benefits, including reductions in inflammation. However, the underlying metabolic mechanisms are poorly understood.
objectiveThis study is designed to evaluate ketone metabolism and immunoregulation during TRE (6-hour feeding and 18-hour fasting) without caloric restriction compared to a conventional dietary regimen (12-hour feeding and 12-hour fasting) in women.
methodsThis is a pilot, prospective, single-arm dietary intervention study in premenopausal women classified as lean and obese, with intraindividual and stratified comparisons. Ketone turnover, immunologic responses, and metabolic profiles will be compared between a conventional dietary regimen (12-hour feeding and 12-hour fasting) at admission and after 3 days of TRE (6-hour feeding and 18-hour fasting).
resultsThe trial commenced in August 2024. As of February 2026, participant enrollment is ongoing. Complete enrollment is expected in the December 2026. Integrated analyses will be reported once data analysis is completed, which is expected in the winter of 2027.
conclusionsThis clinical protocol will evaluate whole-body ketone metabolism and immunoregulatory changes in women during TRE using state-of-the-art stable isotope and immunophenotyping techniques. This study will determine the effects of a time-limited dietary pattern, without caloric restriction, on dynamic measures of immunity and metabolism.
trial registrationClinicalTrials.gov NCT06169137; https://clinicaltrials.gov/study/NCT06169137. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/81063.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Effects of Time-Restricted Eating on Ketone Metabolism and Immunoregulation in Premenopausal Women: Protocol for a Pilot, Prospective, Single-Arm Dietary Intervention Study. · full record | OpenQuestion