Evidence map›Paper›PMID 41790955›Full record

ArticleGenetics and molecular biology2026

The mitogenome mutation repertoire affects progression of Parkinson's Disease.

Gustavo Barra Matos, Camille Sena Dos Santos, Letícia Cota Cavaleiro de Macêdo, Juliana Paiva Dos Santos Diniz, Tatiane Piedade de Sousa, Giovanna Chaves Cavalcante, Caio Santos Silva, Rebecca Lais da Silva Cruz, Dafne Dalledone Moura, Andrea Ribeiro-Dos-Santos and 2 more

Abstract read
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Article in Genetics and molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Gustavo Barra MatosUniversidade Federal do Pará, Instituto de Ciências Biológicas, Laboratório de Genética Humana e Médica, Belém, PA, Brazil.ORCID http://orcid.org/0009-0007-4941-5951
Camille Sena Dos SantosUniversidade Federal do Pará, Instituto de Ciências Biológicas, Laboratório de Genética Humana e Médica, Belém, PA, Brazil.
Letícia Cota Cavaleiro de MacêdoUniversidade Federal do Pará, Instituto de Ciências Biológicas, Laboratório de Genética Humana e Médica, Belém, PA, Brazil.
Juliana Paiva Dos Santos DinizUniversidade Federal do Pará, Instituto de Ciências Biológicas, Laboratório de Genética Humana e Médica, Belém, PA, Brazil.
Tatiane Piedade de SousaUniversidade Federal do Pará, Instituto de Ciências Biológicas, Laboratório de Genética Humana e Médica, Belém, PA, Brazil.
Giovanna Chaves CavalcanteUniversidade Federal do Pará, Instituto de Ciências Biológicas, Laboratório de Genética Humana e Médica, Belém, PA, Brazil.
Caio Santos SilvaUniversidade Federal do Pará, Instituto de Ciências Biológicas, Laboratório de Genética Humana e Médica, Belém, PA, Brazil.
Rebecca Lais da Silva CruzUniversidade Federal do Pará, Instituto de Ciências Biológicas, Laboratório de Genética Humana e Médica, Belém, PA, Brazil.
Dafne Dalledone MouraUniversidade Federal do Pará, Instituto de Tecnologia, Belém, PA, Brazil.
Andrea Ribeiro-Dos-SantosUniversidade Federal do Pará, Instituto de Ciências Biológicas, Laboratório de Genética Humana e Médica, Belém, PA, Brazil.ORCID http://orcid.org/0000-0001-7001-1483
Bruno Lopes Santos-LobatoUniversidade Federal do Pará, Laboratório de Neuropatologia Experimental, Belém, PA, Brazil.ORCID http://orcid.org/0000-0001-9321-5710
Gilderlanio Santana de AraújoUniversidade Federal do Pará, Instituto de Ciências Biológicas, Laboratório de Genética Humana e Médica, Belém, PA, Brazil.ORCID http://orcid.org/0000-0001-9199-9419

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondrial genome variation is a risk factor for Parkinson's disease, but its role in levodopa-induced dyskinesia remains incompletely understood. This study examines the mitochondrial mutation repertoire as a potential biomarker for levodopa-induced dyskinesia in patients with Parkinson's disease. We analyzed the mitogenome using next-generation sequencing data from 42 controls and 45 people with Parkinson's (25 without dyskinesia and 20 with dyskinesia). The mtDNA-server 2 workflow was applied for variant calling analysis. Transition and transversion rates vary during disease progression, especially in patients without levodopa-induced dyskinesia. Although the occurrence of these mutations does not follow a linear pattern, the frequency of transitions modestly increases with age. Specific coding regions (CO1, CO2, CO3, ND4, ND5, and ND6) and the regulatory region (RNR2) exhibited an enrichment of transitions and transversions in patients without dyskinesia. Additionally, we have upgraded the mtDNA-network tool (https://apps.lghm.ufpa.br/mtdna) with an integrated visual component that summarizes the mitochondrial profile in Parkinson's disease. The study highlights dynamic shifts in the mitochondrial mutation repertoire, with clinical implications for underrepresented populations, underscoring the importance of accounting for genetic characteristics across diverse groups.

Identifiers

PMID41790955
PMCPMC12965417

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.