ArticleProceedings of the National Academy of Sciences of the United States of America2026
DNA methylation in invertebrate genomes and cell lineage plasticity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Microbial epigenetic regulation as a multilevel regulatory interface in host-microbe interactions.Gut microbes · 2026Review
- DNA methylation in invertebrate genomes and cell lineage plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The extent of DNA methylation varies widely across animal genomes, from almost undetectable levels in some taxa to high, pervasive methylation in others. Although DNA methylation has been linked to gene regulation, genome defense, and cellular memory, the evolutionary forces shaping its diversity across taxa remain unresolved. Using phylogenetic comparative analysis of 175 invertebrate species spanning 14 phyla, we show that species with greater regenerative capacity exhibit higher genome-wide CpG methylation, independent of phylogenetic relatedness. This relationship suggests that higher genomic DNA methylation is associated with traits indicative of greater somatic lineage renewal and cell lineage plasticity. We propose that, under such conditions, variation in DNA methylation among dividing cells may influence how cell lineages persist, expand, or are replaced within tissues. Thus, we hypothesize that cross-species variation in DNA methylation may reflect differences in somatic lineage renewal and and opportunities for within-body selection.
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Registered trials
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