Evidence map›Paper›PMID 41790942›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

GalNAc-T13 maintains neurite architecture and memory retention via O-GalNAc glycosylation of seizure protein 6.

Yao Deng, Xia Zou, Han Zhang, Xiaoyan Lu, Xingming Zhao, Wenjuan Jia, Yingjiao Xu, Fang Yang, Hisashi Narimatsu, Yan Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yao Deng *Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Center for Chemical Glycobiology, Zhang Jiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai 200240, China.
Xia Zou *Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Center for Chemical Glycobiology, Zhang Jiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai 200240, China.ORCID 0000-0003-0295-0643
Han ZhangKey Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Center for Chemical Glycobiology, Zhang Jiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai 200240, China.
Xiaoyan LuKey Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Center for Chemical Glycobiology, Zhang Jiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai 200240, China.
Xingming ZhaoKey Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Center for Chemical Glycobiology, Zhang Jiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai 200240, China.
Wenjuan JiaKey Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Center for Chemical Glycobiology, Zhang Jiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai 200240, China.
Yingjiao XuKey Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Center for Chemical Glycobiology, Zhang Jiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai 200240, China.
Fang YangKey Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Center for Chemical Glycobiology, Zhang Jiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai 200240, China.
Hisashi NarimatsuShanghai Center for Systems Biomedicine (China)-National Institute of Advanced Industrial Science and Technology (Japan) Joint Medical Glycomics Laboratory, Shanghai Jiao Tong University, Shanghai 200240, China.
Yan ZhangKey Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Center for Chemical Glycobiology, Zhang Jiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai 200240, China.ORCID 0000-0002-4215-3684

Funding

MOST | National Natural Science Foundation of China (NSFC) 92478203 31770850 32371332 32071271
6 · The paper itself

Abstract

Glycosylation, a key and prevalent modification in brain proteins and lipids, is essential for brain development and function. O-GalNAc glycosylation, initiated by the family of polypeptide N-acetylgalactosaminyltransferases (GalNAc-Ts,

Indexed as

MemoryN-AcetylgalactosaminyltransferasesNerve Tissue ProteinsNeuritesAcetylgalactosamineAnimalsBrainGlycosylationHumansMiceMice, KnockoutNeurodevelopmentPolypeptide N-acetylgalactosaminyltransferaseAcetylgalactosamineN-AcetylgalactosaminyltransferasesNerve Tissue ProteinsPolypeptide N-acetylgalactosaminyltransferaseGalNAc-T13neuronal developmentO-glycosylationseizure protein 6 (SEZ6)

Identifiers

PMID41790942
PMCPMC12974515

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.