Evidence map›Paper›PMID 41790891›Full record

ArticleScience advances2026

Polycomb repression works without Siesta, the

Tatyana G Kahn, Andres Garrido, Anastasiya Yushkova, Maria Kim, Alexander Glotov, Sweda Sreekumar, Jan Larsson, Yuri B Schwartz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tatyana G KahnDepartment of Molecular Biology, Epigenetic Cooperation North (EpiCoN), Umeå University, 901 87 Umeå, Sweden.ORCID 0000-0001-6109-6243
Andres GarridoDepartment of Molecular Biology, Epigenetic Cooperation North (EpiCoN), Umeå University, 901 87 Umeå, Sweden.ORCID 0009-0000-7738-4397
Anastasiya YushkovaDepartment of Molecular Biology, Epigenetic Cooperation North (EpiCoN), Umeå University, 901 87 Umeå, Sweden.ORCID 0000-0002-9037-6866
Maria KimDepartment of Molecular Biology, Epigenetic Cooperation North (EpiCoN), Umeå University, 901 87 Umeå, Sweden.
Alexander GlotovDepartment of Molecular Biology, Epigenetic Cooperation North (EpiCoN), Umeå University, 901 87 Umeå, Sweden.
Sweda SreekumarDepartment of Molecular Biology, Epigenetic Cooperation North (EpiCoN), Umeå University, 901 87 Umeå, Sweden.
Jan LarssonDepartment of Molecular Biology, Epigenetic Cooperation North (EpiCoN), Umeå University, 901 87 Umeå, Sweden.ORCID 0000-0003-4373-6790
Yuri B SchwartzDepartment of Molecular Biology, Epigenetic Cooperation North (EpiCoN), Umeå University, 901 87 Umeå, Sweden.ORCID 0000-0003-4790-3920

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polycomb group proteins mediate epigenetic repression via multisubunit complexes, including canonical Polycomb Repressive Complex 1 (PRC1), which monoubiquitylates histone H2A and binds histone H3 trimethylated at lysine-27 (H3K27me3). The RING1 subunit of PRC1, critical for H2A ubiquitylation, forms other complexes. These variant RING1 complexes also ubiquitylate H2A but cannot bind H3K27me3, and their role in epigenetic repression is debated. Using

Indexed as

Drosophila melanogasterDrosophila ProteinsEpigenetic RepressionPolycomb-Group ProteinsPolycomb Repressive Complex 1AnimalsGene Expression Regulation, DevelopmentalHistonesUbiquitinationDrosophila ProteinsHistonesPolycomb-Group ProteinsPolycomb Repressive Complex 1

Identifiers

PMID41790891
PMCPMC12965321

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.