ArticleScience advances2026
Time-dependent adaptations of damaged neurons and their microenvironment in the regenerating adult zebrafish spinal cord.
Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Elevated phagocytic capacity directs innate spinal cord repair.Cell reports · 2026Article
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8 authors.
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Abstract
Spinal cord injury (SCI) triggers complex cellular and extracellular responses that disrupt neuronal connectivity and hinder repair. While mammals have limited regenerative abilities, zebrafish achieve functional recovery through coordinated neuroprotection and plasticity. Here, we examined how structural and functional adaptations of damaged spinal neurons interact with extracellular matrix (ECM) dynamics during regeneration in adult zebrafish. We found that injured neurons undergo reversible changes in cellular properties and synaptic input, mediated mainly by glutamatergic signaling. These modifications coincide with a transient ECM reorganization marked by increased deposition of chondroitin sulfate proteoglycans (CSPGs). Enzymatic CSPG degradation paradoxically partially impaired long-term axonal regrowth and locomotor recovery. Thus, CSPG-rich ECM exerts a dual role: initially restricting plasticity but subsequently supporting structural stabilization and regeneration. Our findings highlight a temporally coordinated interplay between neuronal excitability, synaptic remodeling, and ECM reorganization as key determinants of spinal cord repair, offering mechanistic insights for enhancing nervous system regeneration.
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