Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
22 authors.
Tobias StrasdeitInstitute of Neuro- and Sensory Physiology, Medical Faculty, Heinrich Heine University, University Hospital Düsseldorf, 40225 Düsseldorf, Germany.ORCID 0009-0003-4512-3477
Ehsan AminInstitute of Neuro- and Sensory Physiology, Medical Faculty, Heinrich Heine University, University Hospital Düsseldorf, 40225 Düsseldorf, Germany.ORCID 0000-0003-2995-8864
Sebastian ObstDepartment of Biochemistry I-Receptor Biochemistry, Ruhr University Bochum, 44780 Bochum, Germany.ORCID 0009-0003-7279-222X
Barbara BiermannInstitute of Neuro- and Sensory Physiology, Medical Faculty, Heinrich Heine University, University Hospital Düsseldorf, 40225 Düsseldorf, Germany.ORCID 0009-0009-7844-158X
Thomas P NewtonDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.ORCID 0000-0002-2148-525X
Simon Chris KöstersDepartment of Biochemistry I-Receptor Biochemistry, Ruhr University Bochum, 44780 Bochum, Germany.
Marten SchouwinkInstitute of Neuro- and Sensory Physiology, Medical Faculty, Heinrich Heine University, University Hospital Düsseldorf, 40225 Düsseldorf, Germany.
Sergey FedotovInstitute of Neuro- and Sensory Physiology, Medical Faculty, Heinrich Heine University, University Hospital Düsseldorf, 40225 Düsseldorf, Germany.ORCID 0009-0006-2733-8919
Javeria ShaukatDepartment of Biochemistry I-Receptor Biochemistry, Ruhr University Bochum, 44780 Bochum, Germany.
Subhrajit BhattacharyaDepartment of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA 30322, USA.ORCID 0000-0003-1326-0699
Muhammad AslamInstitute of Pathophysiology, Focus Program Translational Neuroscience (FTN), University Medical Center of the Johannes Gutenberg University Mainz, 55128 Mainz, Germany.
Max AnstötzInstitute of Anatomy II, Medical Faculty, Heinrich Heine University, University Hospital Düsseldorf, 40225 Düsseldorf, Germany.ORCID 0000-0003-3071-5835
Faik Nadi OkkaDepartment of Biochemistry I-Receptor Biochemistry, Ruhr University Bochum, 44780 Bochum, Germany.
Oscar Gabriel Sevillano QuispeDepartment of Biochemistry I-Receptor Biochemistry, Ruhr University Bochum, 44780 Bochum, Germany.ORCID 0000-0002-6873-9800
Pascal BouvainExperimental Cardiovascular Imaging, Institute of Molecular Cardiology, Medical Faculty, Heinrich Heine University, University Hospital Düsseldorf, 40225 Düsseldorf, Germany.ORCID 0000-0002-9116-1330
Julia VedyashkinInstitute of Neuro- and Sensory Physiology, Medical Faculty, Heinrich Heine University, University Hospital Düsseldorf, 40225 Düsseldorf, Germany.
Alexander I SobolevskyDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.ORCID 0000-0001-5181-8644
Stephen F TraynelisDepartment of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA 30322, USA.ORCID 0000-0002-3750-9615
Jakob von EngelhardtInstitute of Pathophysiology, Focus Program Translational Neuroscience (FTN), University Medical Center of the Johannes Gutenberg University Mainz, 55128 Mainz, Germany.ORCID 0000-0003-3861-3294
Nadine ErlenhardtInstitute of Neuro- and Sensory Physiology, Medical Faculty, Heinrich Heine University, University Hospital Düsseldorf, 40225 Düsseldorf, Germany.ORCID 0000-0003-3786-5190
Michael HollmannDepartment of Biochemistry I-Receptor Biochemistry, Ruhr University Bochum, 44780 Bochum, Germany.ORCID 0000-0001-8000-7787
Nikolaj KlöckerInstitute of Neuro- and Sensory Physiology, Medical Faculty, Heinrich Heine University, University Hospital Düsseldorf, 40225 Düsseldorf, Germany.ORCID 0000-0002-7864-1348
Funding
Single-Particle Cryo-EM Characterization of AMPA Receptor Functional StatesR01NS107253 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Alexander Sobolevsky · 2018 to 2026
$3.5M
Structure and Function of Ionotropic Glutamate ReceptorsR37NS083660 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Alexander Sobolevsky · 2024 to 2026
$1.7M
Structure Determination of Heterologous and Native AMPA Receptors and their Complexes with Auxiliary SubunitsF31NS147755 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI NEWTON, THOMAS PAYNE · 2025 to 2025
High-fidelity fast excitatory neurotransmission in the mammalian central nervous system is conducted by the AMPA receptor (AMPAR) subfamily of ionotropic glutamate receptors. AMPARs exist as complexes of the pore-lining α subunits GluA1-4 and a number of auxiliary subunits shaping their functional properties. The first discovered family of auxiliary subunits comprises the transmembrane AMPAR regulatory proteins (TARPs). Together with germ cell-specific gene 1-like (GSG1L), they belong to the PMP-22/EMP/MP20/claudin superfamily sharing substantial sequence homology and a 4-transmembrane domain (4-TMD) topology. Here, we identify the claudin Cldn24 as a novel AMPAR auxiliary subunit in cerebellar granule cells (CGCs). Specifically accelerating the recovery of desensitized receptors, Cldn24 counterbalances gating modulation of GluA by TARP-γ2 and GSG1L in CGCs and hence enables fast reactivation of native receptors. These features substantially expand the tuning properties of hitherto known AMPAR auxiliary subunits and render Cldn24 a powerful enhancer of AMPAR fidelity.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Claudin 24-A novel enhancer of AMPA receptor fidelity. · full record | OpenQuestion