Evidence map›Paper›PMID 41790878›Full record

ArticleScience advances2026

Two-dimensional NIR-II AIE nanotheranostic probes with ultralarge Stokes shifts for surgical navigation and ablation of glioma.

Yisheng Liu, Xiang Su, Yong Zhong, Ping Shangguan, Jun Zhu, Zhengqun Luo, Haigang Wu, Dong Wang, Ting Han, Jiefei Wang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yisheng LiuThe Zhongzhou Laboratory for Integrative Biology, Henan International Joint Laboratory of Nanobiomedicine, School of Life Sciences, Henan University, Kaifeng, Henan 475004, China.ORCID 0009-0008-5276-2652
Xiang SuSchool of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, Guangdong 510006, China.ORCID 0000-0002-6346-7666
Yong ZhongKey Laboratory for Special Functional Materials of Ministry of Education, Henan University, Kaifeng 475004, China.ORCID 0000-0003-1446-3148
Ping ShangguanThe Zhongzhou Laboratory for Integrative Biology, Henan International Joint Laboratory of Nanobiomedicine, School of Life Sciences, Henan University, Kaifeng, Henan 475004, China.
Jun ZhuCenter for AIE Research, Guangdong Provincial Key Laboratory of New Energy Materials Service Safety, College of Materials Science and Engineering, Shenzhen University, Shenzhen, Guangdong 518060, China.
Zhengqun LuoThe Zhongzhou Laboratory for Integrative Biology, Henan International Joint Laboratory of Nanobiomedicine, School of Life Sciences, Henan University, Kaifeng, Henan 475004, China.
Haigang WuThe Zhongzhou Laboratory for Integrative Biology, Henan International Joint Laboratory of Nanobiomedicine, School of Life Sciences, Henan University, Kaifeng, Henan 475004, China.ORCID 0000-0002-3045-6370
Dong WangCenter for AIE Research, Guangdong Provincial Key Laboratory of New Energy Materials Service Safety, College of Materials Science and Engineering, Shenzhen University, Shenzhen, Guangdong 518060, China.ORCID 0000-0001-5137-0771
Ting HanCenter for AIE Research, Guangdong Provincial Key Laboratory of New Energy Materials Service Safety, College of Materials Science and Engineering, Shenzhen University, Shenzhen, Guangdong 518060, China.ORCID 0000-0001-7850-1313
Jiefei WangThe Zhongzhou Laboratory for Integrative Biology, Henan International Joint Laboratory of Nanobiomedicine, School of Life Sciences, Henan University, Kaifeng, Henan 475004, China.ORCID 0000-0001-8374-8847
Bingyang ShiThe Zhongzhou Laboratory for Integrative Biology, Henan International Joint Laboratory of Nanobiomedicine, School of Life Sciences, Henan University, Kaifeng, Henan 475004, China.ORCID 0000-0002-1043-3163
Ben Zhong TangGuangdong Basic Research Center of Excellence for Aggregate Science, School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen, Guangdong 518172, China.ORCID 0000-0002-0293-964X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Near-infrared (NIR) fluorescence probes featuring ultralarge Stokes shifts and efficient aggregate-state luminescence are highly desirable for bioimaging yet remain scarce due to formidable synthetic challenges and intricate photophysical modulation. We report a facile one-step click reaction to synthesize a tetracyanoquinodimethane-derived NIR probe (TNQ2) that overcomes the long-standing nonfluorescence limitation while achieving an unprecedented 445-nanometer Stokes shift. TNQ2 self-assembles into the smallest-sized two-dimensional

Indexed as

Brain NeoplasmsFluorescent DyesGliomaTheranostic NanomedicineAnimalsCell Line, TumorHumansInfrared RaysMiceOptical ImagingSpectroscopy, Near-InfraredFluorescent Dyes

Identifiers

PMID41790878
PMCPMC12965306

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.