Evidence map›Paper›PMID 41790563›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Advancing global precision in dementia research: Examining Normative Heterogeneity of Aging and Neurodegeneration in Chinese Elders (ENHANCE).

Boon Lead Tee, Jessica Spat-Lemus, Spencer Xinyi Zhang, Shreya Upendra, Xinge Zhao, GuanXue Chen, Yu Chen, Xin Wen, Anna Yao, FangDa Leng and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Boon Lead TeeMemory and Aging Center, University of California at San Francisco, San Francisco, California, USA.
Jessica Spat-LemusDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Spencer Xinyi ZhangDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Shreya UpendraDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Xinge ZhaoMemory and Aging Center, University of California at San Francisco, San Francisco, California, USA.
GuanXue ChenMemory and Aging Center, University of California at San Francisco, San Francisco, California, USA.
Yu ChenMemory and Aging Center, University of California at San Francisco, San Francisco, California, USA.
Xin WenMemory and Aging Center, University of California at San Francisco, San Francisco, California, USA.
Anna YaoMemory and Aging Center, University of California at San Francisco, San Francisco, California, USA.
FangDa LengMemory and Aging Center, University of California at San Francisco, San Francisco, California, USA.
Clara LiDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Funding

TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
Project 2: Biomarker Analysis, Non-Genetic Risk Factors, and Their Genetic InteractionsU19AG079774 · NIA · UNIVERSITY OF PENNSYLVANIA · PI HELENA Chang CHUI, Gyungah Jun · 2023 to 2026
$39.4M
Research Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Gil Dan Rabinovici · 2019 to 2026
$36.9M
Examining Unique Markers and Risk Factors for AD/ADRD in Foreign- and Native-born Older Chinese Americans: A Study of Social Determinants of Health, Sleep Patterns, Neuroimaging, and Plasma BiomarkersR01AG095513 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Clara Li, Ankit Ashok Parekh · 2025 to 2026
$9.6M
Augmenting Nurse Support and EHR Integration for the Pragmatic Trial of the UCSF-BHAU01NS128913 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Katherine Laurel Possin · 2022 to 2026
$8.2M
Chinese language versions of the National Alzheimer's Coordinating Center's Uniform Data Set version 4: a linguistic and cultural adaptation studyR01AG083840 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Clara Li, Boon Lead Tee · 2023 to 2026
$5.3M
Primary Progressive Aphasia: Cognition, Anatomy and ProgressionRF1NS050915 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA · 2022 to 2022
$4.7M
The impact of bilingualism on cognitive reserve/resilience using socio-demographically and linguistically diverse populationsR01AG080469 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Suvarna Alladi, Ganesh M Babulal · 2023 to 2026
$4.0M
Dynamic Brain Imaging of Speech in Primary Progressive AphasiaR01NS100440 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI, John Francis Houde · 2017 to 2026
$3.6M
Defining trajectories of dynamic biomarkers for C9ORF72 repeat expansion carriersR01AG058233 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEE, SUZEE EURIE · 2018 to 2022
$3.2M
Research Infrastructure for the study of Alzheimer's Disease and Alzheimer's Disease-related dementias in older Asian AmericansUH3AG083258 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Dongming Cai, Clara Li · 2025 to 2026
$2.5M
Training program in the neurology of language and neurodegenerative aphasiasK24DC015544 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA · 2016 to 2025
$1.9M
Alzheimer's Association AACSFD-22-972143 to B.L.T.Alzheimer's Disease Research Center of California P30 AG062422 to B.L.T.NIA NIH HHS P01 AG019724NIA NIH HHS P30 AG062422NIA NIH HHS R01 AG058233NIA NIH HHS R01 AG080469NIA NIH HHS R01 AG083840NIA NIH HHS R01 AG095513NIA NIH HHS R21 AG077649NIA NIH HHS R61 AG083582NIA NIH HHS U19 AG079774NIA NIH HHS UH3 AG083258NIDCD NIH HHS K24 DC015544NIDCD NIH HHS K24DC015544 to B.L.T.NIDCD NIH HHS R01AG058233 to B.L.T.NIDCD NIH HHS R01 NS100440-01 to B.L.T.NIDCD NIH HHS RF1NS050915 to B.L.T.NIH HHS P01AG019724 to B.L.T.NIH HHS R01AG080469 to B.L.T.NIH HHS R01AG080469 to C.LNIH HHS R01AG083840 to B.L.T.NIH HHS R01AG083840 to C.LNIH HHS R01AG095513 to C.LNIH HHS R21AG077649 to C.LNIH HHS R61AG083582 to C.LNIH HHS U01NS128913 to B.L.T.NIH HHS U19AG079774 to B.L.T.NIH HHS UH3AG083258 to C.LNINDS NIH HHS R01 NS100440NINDS NIH HHS RF1 NS050915NINDS NIH HHS U01 NS128913
6 · The paper itself

Abstract

The Examining Normative Heterogeneity of Aging and Neurodegeneration in Chinese Elders (ENHANCE) project addresses gaps in Alzheimer's disease and Alzheimer's disease and related dementias (AD/ADRD) research by prioritizing Chinese-speaking communities-an underrepresented but rapidly growing population in the United States (US) and globally. ENHANCE uses a transadaptation approach to develop cognitive assessments that reflect the language and culture of Cantonese and Mandarin speakers, making tools more relevant and appropriate. The project brings together data from older Chinese American participants at University of California San Francisco (UCSF) and Icahn School of Medicine at Mount Sinai (ISMMS), guided by community input and pilot testing results of research instruments. By combining data from ISMMS, UCSF, and the National Alzheimer's Coordinating Center (NACC), ENHANCE explores meaningful cross-cultural differences in AD/ADRD risk and progression. The goal is to improve diagnostic accuracy and representation in AD/ADRD research. ENHANCE helps make AD/ADRD research more responsive to language and cultural backgrounds in the older Chinese American community, supporting the goal of precision medicine in diverse population.

Indexed as

AgingAlzheimer DiseaseAsianDementiaAgedAged, 80 and overCaliforniaCross-Cultural ComparisonEast Asian PeopleFemaleHumansMaleaging populationsAlzheimer's disease and related dementias (AD/ADRD)Chinese‐speakingExamining Normative Heterogeneity of Aging and Neurodegeneration in Chinese Elders (ENHANCE)transadaptation

Identifiers

PMID41790563
PMCPMC12965372

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.