Evidence map›Paper›PMID 41790392›Full record

ReviewCurrent medical science2026

Trehalose: A Promising Therapeutic Agent for Diverse Pathological Conditions.

Mahboobeh Ghasemzadeh Rahbardar, Prashant Kesharwani, Amirhossein Sahebkar

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Obesity and Eye Diseases.Nutrients · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mahboobeh Ghasemzadeh RahbardarClinical Research Development Unit, Shahid Hasheminejad Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Prashant KesharwaniNext-Generation Translational Nanomedicine Laboratory, Department of Pharmaceutical Sciences, Dr. Harisingh Gour Vishwavidyalaya (A Central University), Sagar, Madhya Pradesh, 470003, India. prashantdops@gmail.com.ORCID http://orcid.org/0000-0002-0890-769X
Amirhossein SahebkarBiotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. sahebkara@mums.ac.ir.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Trehalose, a naturally occurring disaccharide, is gaining recognition for its therapeutic potential across a wide range of disorders. This review highlights the increasing importance of trehalose in clinical research and its applications in disease management. The unique biochemical properties of trehalose, including its ability to increase stress resistance and protect cellular structures, make it a promising therapeutic agent for various pathological conditions. Trehalose has demonstrated potential in addressing metabolic disorders such as diabetes and obesity by regulating glucose homeostasis, improving insulin sensitivity, and modulating lipid metabolism. Additionally, it has shown promise in cancer treatment by inhibiting tumor growth and promoting cell death. Beneficial effects have also been observed in models of cardiovascular diseases, ocular and dental conditions, osteoarthritis, Niemann-Pick disease, and genetic disorders. While existing clinical studies provide valuable insights into the therapeutic potential of trehalose, further research is needed to optimize its dosage, elucidate its mechanisms of action, and conduct large-scale trials to establish its efficacy and safety. In conclusion, trehalose represents a promising therapeutic compound with broad applications, offering a compelling avenue for future research and the development of innovative treatment strategies.

Indexed as

TrehaloseAnimalsCardiovascular DiseasesHumansInsulin ResistanceLipid MetabolismNeoplasmsNiemann-Pick DiseasesObesityOsteoarthritisTrehaloseCardiovascular diseasesDiabetes mellitusDry eye syndromeInsulin resistanceNiemann-Pick diseaseObesityOsteoarthritisTrehalose

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.