Evidence map›Paper›PMID 41789937›Full record

ArticleJournal of periodontology2026

Type I interferon-induced CD169

Jiawei Lu, Zehui Xiong, Xiao Wu, Yanan Yang, Jinyi Zhang, Lijun Luo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of periodontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jiawei LuShanghai Engineering Research Center of Tooth Restoration and Regeneration & Tongji Research Institute of Stomatology & Department of Periodontics, Stomatological Hospital and Dental School, Tongji University, Shanghai, China.ORCID https://orcid.org/0000-0002-7304-7067
Zehui XiongShanghai Engineering Research Center of Tooth Restoration and Regeneration & Tongji Research Institute of Stomatology & Department of Periodontics, Stomatological Hospital and Dental School, Tongji University, Shanghai, China.
Xiao WuShanghai Engineering Research Center of Tooth Restoration and Regeneration & Tongji Research Institute of Stomatology & Department of Periodontics, Stomatological Hospital and Dental School, Tongji University, Shanghai, China.ORCID https://orcid.org/0009-0004-4292-0259
Yanan YangShanghai Engineering Research Center of Tooth Restoration and Regeneration & Tongji Research Institute of Stomatology & Department of Periodontics, Stomatological Hospital and Dental School, Tongji University, Shanghai, China.ORCID https://orcid.org/0000-0003-4981-3582
Jinyi ZhangShanghai Engineering Research Center of Tooth Restoration and Regeneration & Tongji Research Institute of Stomatology & Department of Periodontics, Stomatological Hospital and Dental School, Tongji University, Shanghai, China.
Lijun LuoShanghai Engineering Research Center of Tooth Restoration and Regeneration & Tongji Research Institute of Stomatology & Department of Periodontics, Stomatological Hospital and Dental School, Tongji University, Shanghai, China.ORCID https://orcid.org/0000-0001-7137-1739

Funding

National Natural Science Foundation of China 82071123National Natural Science Foundation of China 82370971
6 · The paper itself

Abstract

backgroundThis study aims to investigate the transcriptional characteristics and differentiation microenvironment of the CD169

methodsSingle-cell RNA sequencing landscape of periodontal tissues from healthy controls (n = 8) and periodontitis patients (n = 10) were constructed. Immunohistochemical staining was used to detect the percentage of CD169

resultsThe phenotypes of CD169

conclusionsOur findings indicate that type I interferons produced by fibroblasts in periodontal tissues induce monocytes to differentiate into macrophages with a CD169 PLAIN LANGUAGE SUMMARY: Periodontitis is one of the major diseases that threaten human health. CD169

Indexed as

Interferon Type IMacrophagesPeriodontitisSialic Acid Binding Ig-like Lectin 1AdultAnimalsCell DifferentiationFemaleHumansMaleMiceReceptor, Interferon alpha-betaInterferon Type IReceptor, Interferon alpha-betaSialic Acid Binding Ig-like Lectin 1SIGLEC1 protein, humanCD169+ macrophagesmacrophagesperiodontitissialic acid binding Ig like lectin 1type I interferons

Identifiers

PMID41789937
PMCPMC13380365

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.